Evidence map›Paper›PMID 41620580›Full record

ArticleMolecular psychiatry2026

Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling.

Cameron James Watson, Johan Zvrskovec, Giuseppe Pierpaolo Merola, Lachlan Gilchrist, Senta M Haussler, Miryam Schattner, Chris Wai Hang Lo, Gerome Breen, Robin M Murray, Cathryn Μ Lewis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cameron James WatsonSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2346-4636
Johan ZvrskovecSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8862-0874
Giuseppe Pierpaolo MerolaSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-9695-0972
Lachlan GilchristSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Senta M HausslerSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0009-0008-2447-2324
Miryam SchattnerSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0009-0006-3037-6588
Chris Wai Hang LoSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2053-1792
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0829-0519
Cathryn Μ LewisSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8249-8476
Evangelos VassosSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. evangelos.vassos@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6363-0438

Funding

DH | National Institute for Health Research (NIHR) ACF-2022-17-009
6 · The paper itself

Abstract

The genetic relationship between schizophrenia, IQ, and educational attainment (EA) is complex. Schizophrenia polygenic scores (PGS) are linked to lower IQ, whilst higher IQ-PGS correlates with reduced schizophrenia risk. Paradoxically, genetic predisposition to higher EA has been associated with increased schizophrenia risk, a relationship potentially confounded by genetic overlap between schizophrenia and bipolar disorder. Using a latent-variable Genomic Structural Equation Modelling approach to GWAS summary statistics for schizophrenia and bipolar disorder, we dissected the genetic contribution to schizophrenia, identifying 63 SNPs specifically associated with schizophrenia (SZ

Indexed as

SchizophreniaBipolar DisorderCognitionEducational StatusFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyGenomicsHumansIntelligenceMaleMultifactorial InheritancePolymorphism, Single Nucleotide

Identifiers

PMID41620580
PMCPMC13190233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.