Evidence map›Paper›PMID 41620490›Full record

ArticleScientific reports2026

The expression profiling of serum circPHLPP2 and LncRNA ILF3 in colorectal cancer patients.

Ahmed Alobaida, Taslim Alhilal, Alia D Alshammari, Ahmed Elshafei, Emad Gamil Khidr

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ahmed AlobaidaDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia.
Taslim AlhilalSchool of Pharmacy, University of Texas at El Paso, El Paso, TX, 81462, USA.
Alia D AlshammariDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia.
Ahmed ElshafeiDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy for Boys, Al-Azhar University, Nasr City, Cairo, 11231, Egypt.
Emad Gamil KhidrDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy for Boys, Al-Azhar University, Nasr City, Cairo, 11231, Egypt. Emadgamil2003@azhar.edu.eg.ORCID http://orcid.org/0000-0002-7395-234X

Funding

Deputy for Research & Innovation, Ministry of Education through Initiative of Institutional Funding at University of Ha'il - Saudi Arabia IFP-22 111
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide, highlighting the need for new non-invasive biomarkers for early diagnosis and prognosis. This study explored the expression of two non-coding RNAs, circular RNA PHLPP2 (circPHLPP2) and long non-coding RNA ILF3-AS1 (lncRNA ILF3-AS1), in CRC patients and assessed their clinical significance. A total of 220 participants were enrolled, including 130 CRC patients (grouped by cancer stage) and 90 healthy individuals. Serum levels of circPHLPP2 and lncRNA ILF3-AS1 were measured using real-time PCR, and traditional tumor markers CEA and CA19-9 were evaluated by immunoassay. Both non-coding RNAs were significantly elevated in CRC patients and showed a progressive increase across cancer stages, reaching the highest levels in metastatic cases. Diagnostic analysis revealed that circPHLPP2 and lncRNA ILF3-AS1 had stronger diagnostic performance than conventional markers. Furthermore, lncRNA ILF3-AS1 was identified as an independent predictor of metastatic CRC. These findings suggest that circPHLPP2 and lncRNA ILF3-AS1 could serve as promising biomarkers for the diagnosis and staging of CRC.

Indexed as

Colorectal NeoplasmsNuclear Factor 90 ProteinsPhosphoprotein PhosphatasesRNA, CircularRNA, Long NoncodingAgedBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm StagingPrognosisBiomarkers, TumorILF3 protein, humanNuclear Factor 90 ProteinsPHLPP2 protein, humanPhosphoprotein PhosphatasesRNA, CircularRNA, Long NoncodingBiomarkerCircPHLPP2Colorectal cancerLncRNA ILF3-AS1Metastasis

Identifiers

PMID41620490
PMCPMC12864813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.