ArticleScientific reports2026
Effect of low-temperature intracanal sodium hypochlorite on root surface temperature reduction and organic tissue dissolution: an in vitro study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Clinical and biochemical effects of cryotherapy protocols on mandibular premolars with symptomatic apical periodontitis: a randomized clinical trial.Clinical oral investigations · 2026Trial
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7 authors.
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Abstract
introductionThis study aimed to evaluate the effect of low-temperature intracanal sodium hypochlorite (NaOCl) irrigation on root surface temperature reduction and its ability to dissolve organic tissue.
methodsExtracted mandibular premolars were accessed and instrumented. Final irrigation protocols with NaOCl, at two different temperatures: room temperature (control) and 2.5 °C (experimental), were applied. Initial and the lowest root surface temperatures were recorded using a digital thermometer. Organic tissue dissolution was assessed using glass capillaries, filled with catgut, attached to 3D-printed maxillary incisors exposed to the same irrigation protocols. Data was statistically analyzed.
resultsLow-temperature NaOCl irrigation led to a significantly greater reduction in root surface temperature compared to room temperature NaOCl (p < 0.05). Both irrigation protocols showed similar organic tissue dissolution, with no significant difference between them (p > 0.05).
conclusionIntracanal irrigation with low-temperature NaOCl effectively reduced root surface temperature while maintaining its organic tissue dissolution capacity. CLINICAL RELEVANCE: The use of cold sodium hypochlorite represents a simple and effective intracanal cryotherapy approach that may help to minimize postoperative inflammation while preserving the chemical efficacy of the irrigation during endodontic treatment.
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