Evidence map›Paper›PMID 41620444›Full record

ArticleNPJ biofilms and microbiomes2026

Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.

Xinghong Zhou, Xiaoyu Liu, Baizhao Peng, Ying Yang, Hanqi Lu, Dexian Li, Yijian Deng, Zihao Jiang, Chuanghai Wu, Wen Fang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinghong Zhou *Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiaoyu Liu *Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangzhou, China.
Baizhao Peng *Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ying Yang *Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Hanqi LuDongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.
Dexian LiNanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yijian DengSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zihao JiangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Chuanghai WuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Wen FangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yanting YouSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Hiu Yee KwanSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Xiaoshan ZhaoNanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. zhaoxs@smu.edu.cn.
Yanyan LiuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. 799042406@qq.com.

Funding

Guangzhou Science and Technology Plan Project 2024B03J1343Joint Funds of National Natural Science Foundation of China U22A20365National Natural Science Foundation of China T2341019National Natural Science Foundation of China-Guangdong Joint Fund 2023A1515110757Science and Technology Program of Dongguan, China 20231800913372the Key Project of National Natural Science Foundation of China 81830117The Major scientific and technological project of Guangzhou Municipal Health Commission 20252D003
6 · The paper itself

Abstract

Renal injury is a common complication of hyperuricemia (HUA), which has been recognized as an independent risk factor for chronic kidney disease (CKD). The gut-kidney axis theory suggests that targeting the gut microbiota may be a potential treatment option for kidney disease. In this study, we utilized a spontaneous HUA rat model to demonstrate that Simiao decoction (SMD), a traditional Chinese medicine formula, can effectively alleviate HUA-induced renal injury by modulating gut microbiota and bacterial metabolism of tryptophan and tyrosine, thereby reducing gut-derived uremic toxins such as indoxyl sulfate (IS) and p-Cresol (PC). Fecal microbiota transplantation (FMT) further confirmed that the therapeutic effect of SMD was mediated by gut microbiota. Finally, in vitro studies revealed that IS promotes epithelial-mesenchymal transition (EMT) while PC induces cellular senescence in tubular cells. Collectively, our findings suggest that SMD can effectively alleviate HUA-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins. This study sheds light on a novel mechanism by which SMD exerts its effects on HUA-induced renal injury.

Indexed as

Drugs, Chinese HerbalDysbiosisGastrointestinal MicrobiomeHyperuricemiaUremic ToxinsAnimalsBacteriaCresolsDisease Models, AnimalEpithelial-Mesenchymal TransitionFecal Microbiota TransplantationIndicanKidneyMaleRatsRats, Sprague-DawleyCresolsDrugs, Chinese HerbalIndicanTryptophanTyrosineUremic Toxins

Identifiers

PMID41620444
PMCPMC12963564

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.