ArticleExperimental physiology2026
Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ovariectomy, but not moderate intermittent hypoxia, promotes respiratory instability and risk of obesity in adult female rats.Experimental physiology · 2026Article
- Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension.Experimental physiology · 2026Article
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Authors and funding
7 authors.
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Abstract
Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex-specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats. Following birth, rats were either subjected to NMS (3 h/day from postnatal days 3 to 12) or raised under standard conditions (CTRL). Cardiovascular and neuroendocrine functions were evaluated at three distinct ages: young adult (12 weeks), middle-age (35 weeks) and old (64 weeks). Measurements included hormonal profile (multiplex assay), mean arterial blood pressure (MAP; tail cuff method), activity of the plasma angiotensin-converting enzymes (ACE and ACE2), and activation of the paraventricular nucleus of the hypothalamus (PVN; FosB immunolabelling). Age-related decline in 17β-oestradiol (E
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