Evidence map›Paper›PMID 41620173›Full record

ArticleJournal of advanced research2026

Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin.

Zeyu Wang, Jiahui Zhu, Yuting Wang, Tianxing Hu, Shuai Chen, Senlin Xu, Yaoying Li, Xiang Liao, Shanshan Liang, Yang Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zeyu WangCenter for Neurointelligence, School of Medicine, Chongqing University, Chongqing 400030, China; LFC Laboratory and Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing 400064, China.
Jiahui ZhuGuangxi Key Laboratory of Special Biomedicine & Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China.
Yuting WangDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China.
Tianxing HuDepartment of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing 400038, China.
Shuai ChenGuangxi Key Laboratory of Special Biomedicine & Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China; School of Physical Science and Engineering Technology, Guangxi University, Nanning 530004, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Senlin XuInstitute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing 400038, China.
Yaoying LiDepartment of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing 400038, China.
Xiang LiaoCenter for Neurointelligence, School of Medicine, Chongqing University, Chongqing 400030, China.
Shanshan LiangLFC Laboratory and Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing 400064, China.
Yang LiDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Xuanyue WangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing 400038, China.
Sunny C LiNewLight Neuroscience Unit, Chongqing 400064, China; MIMO Research Unit, Chongqing 400064, China.
Yan YangSchool of Materials Science and Engineering, Chongqing University of Technology, Chongqing 400054, China.
Hongbo JiaGuangxi Key Laboratory of Special Biomedicine & Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China; School of Physical Science and Engineering Technology, Guangxi University, Nanning 530004, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China; Combinatorial NeuroImaging Core Facility, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany.
Xiaowei ChenLFC Laboratory and Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing 400064, China; Brain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing 400038, China.
Xing FanDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: fanxing.612@163.com.
Lan GeDepartment of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing 400038, China. Electronic address: stove9925@tmmu.edu.cn.
Jianxiong ZhangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing 400038, China. Electronic address: jianxiong_zhang1988@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStimulating collagen production is a key strategy for enhancing skin vitality and counteracting aging. However, current methods to boost collagen synthesis often entail pain and tissue trauma. There is a compelling need for painless, non-invasive approaches to effectively increase skin collagen.

objectivesTo investigate the effects of mid-infrared modulation (MIMO) on skin collagen deposition across multiple biological scales, from human and animal models in vivo to human dermal fibroblasts in vitro.

methodsWe determined optimal MIMO irradiation parameters (energy, duration) in human and animal skin. Effects on collagen deposition were evaluated in vivo (human, mouse) and in vitro (human dermal fibroblasts). Levels of inflammatory and collagen metabolism-related proteins were measured by ELISA.

resultsMIMO irradiation (70 mW/cm

conclusionsMIMO represents a safe, non-invasive, and painless approach for effectively enhancing skin collagen deposition in vivo.

Indexed as

CollagenInfrared RaysSkinAnimalsFemaleFibroblastsHSP47 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHumansMaleMatrix Metalloproteinase 1MiceSkin AgingTransforming Growth Factor betaCollagenHSP47 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsMatrix Metalloproteinase 1Transforming Growth Factor betaAgingCollagenMid-infraredNon-invasiveSkin

Identifiers

PMID41620173
PMCPMC13669616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.