Evidence map›Paper›PMID 41619976›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Motion-compensated spin-echo cardiac diffusion tensor imaging in multiple cardiac phases using an ultrahigh gradient strength scanner.

Shubhajit Paul, Camila Munoz, Pedro F Ferreira, C John Evans, Sonya Foley, Fabrizio Fasano, Derek K Jones, Dudley J Pennell, Sonia Nielles-Vallespin, Andrew D Scott

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shubhajit PaulCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Camila MunozCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Pedro F FerreiraCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
C John EvansCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Sonya FoleyCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Fabrizio FasanoSiemens Healthcare Ltd, Camberly, UK; Siemens Healthcare GmbH, Erlangen, Germany.
Derek K JonesCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Dudley J PennellCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Sonia Nielles-VallespinCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Andrew D ScottCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: Andrew.scott@imperial.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac diffusion tensor imaging (cDTI) has traditionally relied on inefficient stimulated echo techniques to robustly assess microstructural changes over the cardiac cycle. Ultrahigh gradient strength systems (>80mT/m) allow shorter motion-compensated diffusion encoding. This study compares the ability of high and ultrahigh strength gradient systems to provide systolic and diastolic motion-compensated spin echo (MCSE) cDTI.

methodsSecond-order MCSE sequences were developed for a research-only Siemens 3T Connectom (300mT/m maximum gradient amplitude per axis), and breath-hold cDTI was acquired at peak systole and end diastole. Acquisitions used the maximum achievable gradient strength (G

resultsTwenty-two healthy subjects were recruited. 20/21 and 21/22 systolic acquisitions at G

conclusionUltrahigh-strength gradient systems deliver higher SNR for MCSE and more robust imaging in diastole. While further work is required to further improve the reliability in diastole, at ultrahigh gradient strengths, cDTI using MCSE can identify dynamic changes in the cardiac microstructure. These findings will lead to more widespread use of multiphase MCSE in cDTI clinical research.

Indexed as

Diffusion Tensor ImagingVentricular Function, LeftAdultBreath HoldingDiastoleFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedMalePredictive Value of TestsReproducibility of ResultsSystoleTime FactorsCardiac diffusion tensorHigh gradient strengthMotion-compensated diffusion encoding

Identifiers

PMID41619976
PMCPMC13207544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.