ArticleThe ocular surface2026
Lacrimal gland duct obstruction and dacryops: Unravelling its pathogenesis with proteomics and cellular profiling.
Article in The ocular surface, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo understand the pathogenesis of the main lacrimal gland dacryops (ductular cyst) using proteomics and cellular profiling.
methodsFour patients (mean age, 42.2 ± 18.4 years) with dacryops underwent cyst excision following the aspiration of the cyst contents. Cyst contents were processed using mass spectrometry and compared with eight healthy tear samples. The cyst wall was processed for histology (H&E, Masson trichrome), epithelial (Aquaporin 5, CK15, CK19), stromal (Vimentin), neural (beta-III tubulin, NCAM), and immune cell markers (CD3, CD20, CD138, myeloperoxidase, CD68).
resultsThe cyst lining was cuboidal to squamous in three cases (CK19+, ductal origin), and exhibited goblet cell metaplasia in one case. Compared to normal ducts, the dacryops cyst wall lacked expression of AQP5 and beta-III tubulin. Subepithelial fibrosis and strong vimentin positivity were observed in all specimens, along with mild to moderate inflammation. Infiltrating immune cells were CD20
conclusionDacryops involves reactive ductular ectasia secondary to inflammation, resulting in increased MMPs, fibrosis, and loss of the periductal neural network. The cyst fluid is rich in apolipoproteins, immunoglobulins, and complement factors. Future research could focus on the lipidomics of the cyst fluid.
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