Evidence map›Paper›PMID 41619893›Full record

Observational studyBone2026

Sex-specific biomarkers predict bone mineral density loss at the contralateral hip after hip fracture.

Alan M Rathbun, Michelle D Shardell, Alice S Ryan, Joseph P Stains, Denise L Orwig, Jay S Magaziner, Gerard P Slobogean, Marc C Hochberg

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Bone, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alan M RathbunDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: arathbun@som.umaryland.edu.
Michelle D ShardellDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Alice S RyanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatric Research Education and Clinical Center, VA Maryland Health Care System, Baltimore, MD, USA.
Joseph P StainsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Denise L OrwigDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Jay S MagazinerDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Gerard P SlobogeanDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Marc C HochbergDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in MeR01AG029315 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 2007 to 2011
$4.1M
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of MenopauseR01AG069915 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI REBECCA M. BROTMAN, Michelle Denise Shardell · 2021 to 2026
$3.1M
Methods to Test Biomarkers of Aging as Shared Determinants of Alzheimers Disease and Related Dementias and Physical DisabilityR01AG079854 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2023 to 2025
$2.3M
Statistical Models and Mechanisms Linking Biomarkers of Aging to Cognitive-Physical Decline and DementiaRF1NS128360 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2022 to 2022
$2.2M
A Feasibility and Pilot Study of Combined Treatment Protocol using Aerobic Exercise and Duloxetine in Older Adults with Symptomatic Knee Osteoarthritis and Comorbid DepressionK01AG064041 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI RATHBUN, ALAN MICHAEL · 2019 to 2023
$619k
Epidemiology of the Inverse Comorbidity of Dementia and Cancer: Statistical Methods and Biological MechanismsR03AG070178 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2021 to 2021
$309k
NIANational Institute on Aging & NIH National Institutes of Health HHS K01- AG064041NIANational Institute on Aging & NIH National Institutes of Health HHS R01-AG048069NIANational Institute on Aging & NIH National Institutes of Health HHS R01-AG079854NIANational Institute on Aging & NIH National Institutes of Health HHS R03 AG070178NIANational Institute on Aging & NIH National Institutes of Health HHS R37 AG009901NIA NIH HHS K01 AG064041NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG029315NIA NIH HHS R01-AG029315NIA NIH HHS R01 AG048069NIA NIH HHS R01 AG069915NIA NIH HHS R01 AG079854NIA NIH HHS R03 AG070178NIA NIH HHS R37 AG009901NINDS NIH HHS RF1 NS128360RRD VA IK6 RX003977
6 · The paper itself

Abstract

objectiveTo identify inflammatory and hormonal biomarkers that predict bone loss at the contralateral (non-fractured) hip following hip fracture in males and females.

methodsWhite participants who were not receiving pre-fracture glucocorticoids, sex-hormone therapy, or bone-active medications (100 males, 76 females) with hip fractures. Data were collected within 22 days of hip fracture and at 2, 6, and 12 months follow-up. Biomarkers were categorized into tertiles: estradiol, 25-hydroxyvitamin D3/D2, intact parathyroid hormone (iPTH), interleukin-1 receptor antagonist (IL-1RA), interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1), soluble tumor necrosis factor-α receptor 1, sex hormone-binding globulin, and testosterone. Femoral neck bone mineral density (BMD) at the contralateral hip was assessed, and losses exceeding the mean decline were classified as greater than average. Logistic regression models, stratified by sex, were adjusted for confounders and evaluated selected biomarker associations.

resultsAmong males, the 2nd (OR = 4.79, P = 0.012) and 3rd (OR = 6.36, P = 0.005) IGF-1 tertiles were associated with greater odds of BMD loss than the 1st tertile. The 3rd iPTH tertile (OR = 3.79, P = 0.037) was similarly associated with increased odds. Among females, the 3rd (OR = 0.20, P = 0.031) IL-1RA tertile was associated with lower odds of BMD loss compared to the 1st tertile, while the 2nd IL-6 tertile (OR = 5.99, P = 0.036) was associated with higher odds.

conclusionThese findings suggest that inflammatory and hormonal biomarkers may be sex-specific predictors of accelerated BMD loss following hip fracture.

Indexed as

Bone DensityBone ResorptionHipHip FracturesSex CharacteristicsAgedAged, 80 and overBiomarkersFemaleFemur NeckFollow-Up StudiesGonadal Steroid HormonesHumansLogistic ModelsLongitudinal StudiesMaleBiomarkersGonadal Steroid HormonesAgingBiomarkersBone mineral densityHip fractureOsteoporosis

Identifiers

PMID41619893
PMCPMC13532411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.