Evidence map›Paper›PMID 41619722›Full record

ArticleCell reports. Medicine2026

A pan-cancer single-cell transcriptomic atlas of human bone metastases.

Shuoer Wang, Fen Ma, Dongliang Wang, Qian Yu, Haoyu Zheng, Ziqing Chen, Songjiao Zhao, Lun Xu, Qingrong Ye, Yiwen Tan and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Shuoer WangDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Genetic Evolution & Animal Models, Chinese Academy of Sciences, Shanghai 200031, China; Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Fen MaInstitute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Genetic Evolution & Animal Models, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Key Laboratory of Compound Chinese Medicines, The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Dongliang WangDepartment of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai 200032, China.
Qian YuDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Haoyu ZhengDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Ziqing ChenEpigenic Therapeutics, Shanghai 201315, China.
Songjiao ZhaoDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Lun XuDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Qingrong YeDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yiwen TanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China; National Clinical Research Center for Interventional Medicine& Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China.
Wending HuangDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhengwang SunDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhiqiang WuDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Weiluo CaiDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Meng FangDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Mo ChengDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yingzheng JiDepartment of Orthopedic, Naval Medical Center of PLA, Second Military Medical University, Shanghai 200052, China.
Yunkui ZhangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Bingxin GuDepartment of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai 200032, China.
Shaoli SongDepartment of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai 200032, China.
Yang ChenEpigenic Therapeutics, Shanghai 201315, China.
Jiwei ZhangShanghai Key Laboratory of Compound Chinese Medicines, The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: joezhang@shutcm.edu.cn.
Yang ShaoGynecology Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China. Electronic address: thierryhenrysy@gmail.com.
Wangjun YanDepartment of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: yanwj@fudan.edu.cn.
Yidi SunInstitute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Genetic Evolution & Animal Models, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: ydsun@ion.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is a common site for cancer metastasis, yet the mechanisms driving human spinal bone metastases (BMs) are poorly understood. Here, we obtained a single-cell RNA sequencing (scRNA-seq) atlas of 62 BMs across 13 different origins, along with paired primary tumor and normal bone marrow. Unsupervised clustering of cancer cell functional programs revealed 3 groups with distinct prognosis and tumor microenvironment. Integrative analysis with large-scale primary and metastatic pan-cancer and healthy bone marrow scRNA-seq datasets revealed SELE-positive endothelial cells, osteoblasts, and osteoclasts associated with cancer cell proliferation. We also identified BM-enriched exhausted CD8

Indexed as

Bone NeoplasmsSingle-Cell AnalysisTranscriptomeAnimalsCD8-Positive T-LymphocytesCell ProliferationGene Expression Regulation, NeoplasticHumansMiceOsteoblastsSingle-Cell Gene Expression AnalysisT-Cell ExhaustionTumor Microenvironmentbone metastasisimmunotherapypan-cancersingle-cell transcriptome atlas

Identifiers

PMID41619722
PMCPMC12923970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.