SynthesisBrain and behavior2026
Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature.
Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature.Brain and behavior · 2026Pooled it
- Unawareness of motor deficit in Huntington's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The potential of vitamins in Huntington's disease: bridging mechanistic evidence with translational limitations and future strategies.Metabolic brain disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review examines executive dysfunction in Huntington's disease (HD), an inherited neurodegenerative disorder characterized by cognitive alterations that may emerge years before the onset of motor symptoms. The objective of this review is to provide an updated and comprehensive synthesis of executive function deficits observed across the clinical spectrum of HD-from presymptomatic to the more advanced symptomatic phases-and to examine how these deficits relate to underlying neurobiological changes identified through neuroimaging and neurophysiological studies.
methodA systematic review was conducted encompassing studies published up to November 2024 and listed on PubMed database. Inclusion criteria focused on clinical and experimental studies involving executive functions in HD at different stages. A total of 3487 articles were screened, of which 115 met the eligibility criteria. The present review synthesizes recent longitudinal and multimodal findings, with a specific focus on the presymptomatic and prodromal phases, offering an integrative perspective that links cognitive, structural, and functional markers of executive dysfunction. FINDING: The findings reveal a selective, stage-dependent pattern of executive dysfunction. Early alterations are most consistently observed in psychomotor speed, cognitive flexibility, response inhibition, and working memory updating, whereas later stages exhibit broader impairments in planning and attention, accompanied by overall functional decline. Among neuroimaging markers, striatal atrophy, frontostriatal disconnection, and reduced prefrontal activation during executive tasks emerge as the most robust correlates of executive dysfunction.
conclusionThese results underscore the relevance of early cognitive assessment for detecting subtle executive changes prior to overt motor symptoms, and the need for longitudinal, multimodal and computational approaches integrating behavioral, neuroimaging, and electrophysiological data. Future research should prioritize prospective tracking of presymptomatic individuals, the standardization of executive function measures, and the identification of biologically markers to inform early interventions and monitor treatment efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.