Evidence map›Paper›PMID 41619290›Full record

ArticleMedical physics2026

Development and dosimetric evaluation of a freely deformable

Naonori Hu, Ryo Kakino, Akinori Sasaki, Mai Nojiri, Kazuhiko Akita, Syuushi Yoshikawa, Yasushi Kohigashi, Yuki Yoshino, Satoshi Takeno, Teruhito Aihara and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Naonori HuKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Ryo KakinoKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Akinori SasakiKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Mai NojiriKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Kazuhiko AkitaKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Syuushi YoshikawaBNCT Joint Clinical Institute, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Yasushi KohigashiKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Yuki YoshinoKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Satoshi TakenoKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Teruhito AiharaBNCT Joint Clinical Institute, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Takushi TakataParticle Radiation Oncology Research Center, Kyoto University Institute for Integrated Radiation and Nuclear Science, Osaka, Japan.
Hiroki TanakaParticle Radiation Oncology Research Center, Kyoto University Institute for Integrated Radiation and Nuclear Science, Osaka, Japan.
Keiji NiheiKansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Koji OnoBNCT Joint Clinical Institute, Osaka Medical and Pharmaceutical University, Osaka, Japan.

Funding

JSPS KAKENHI JP21K20521JSPS KAKENHI JP24K18810
6 · The paper itself

Abstract

backgroundBoron neutron capture therapy (BNCT) enables selective tumor irradiation by exploiting the high-linear energy transfer particles generated from neutron interactions with PURPOSE: To develop a freely deformable LiF-polyethylene neutron shield and assess its impact on neutron/gamma attenuation and clinical organ at-risk sparing in head and neck BNCT.

methodsA freely deformable neutron shielding device was constructed using polyethylene beads loaded with lithium fluoride encapsulated in a vacuum-sealed cushion. Neutron and gamma-ray attenuation were measured in a water phantom under clinical conditions using an accelerator-based BNCT system (NeuCure®, Kansai BNCT Medical Center). Measurements were compared with a solid LiF-polyethylene block and validated through Monte Carlo-based simulations in a commercial treatment planning system. Three representative head and neck cases were further simulated to assess clinical dosimetric effects.

resultsThe deformable shielding device reduced the thermal neutron flux by approximately 50%, compared with 60% for the solid LiF-polyethylene block. Simulated head and neck treatments demonstrated significant OAR dose reductions (up to 46.6% in pharyngeal mucosa D

conclusionsThe freely deformable LiF-based neutron shielding device effectively attenuated stray neutron dose while maintaining target coverage in BNCT. Its adaptability and reusability make it a practical adjunct for patient-specific dose optimization in clinical BNCT applications.

Indexed as

Boron Neutron Capture TherapyLithiumNeutronsRadiation ProtectionHead and Neck NeoplasmsHumansMonte Carlo MethodPhantoms, ImagingRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedLithiumBNCTMonte Carlo simulationneutron shielding

Identifiers

PMID41619290
PMCPMC12860538

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.