Evidence map›Paper›PMID 41619178›Full record

ArticleMacromolecular rapid communications2026

Hydrogels Incorporating Donor-Acceptor Stenhouse Adducts as a Platform for Photoinduced, On-Off Switchable Release of Small Molecule Cargos.

Tristan N Dell, Ana Cammack-Najera, Rea Tresa, Farzina Matubbar, Beyzanur Kaya, Uthaya Lathan, Mohamed Chami, Ray G DiNardi, Omar Rifaie-Graham, Jonathan P Wojciechowski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tristan N DellDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-8960-4334
Ana Cammack-NajeraDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-5043-5940
Rea TresaDepartment of Physiology, Anatomy and Genetics, Department of Engineering Science, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Farzina MatubbarDepartment of Chemistry, School of Physical and Chemical Sciences, Queen Mary University of London, London, UK.
Beyzanur KayaDepartment of Chemistry, School of Physical and Chemical Sciences, Queen Mary University of London, London, UK.
Uthaya LathanDepartment of Chemistry, School of Physical and Chemical Sciences, Queen Mary University of London, London, UK.
Mohamed ChamiBioEM Lab, Biozentrum, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-8733-055X
Ray G DiNardiDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-8864-5692
Omar Rifaie-GrahamDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-1403-0537
Jonathan P WojciechowskiDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-6272-515X
Molly M StevensDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7335-266X

Funding

British Heart Foundation FS/4yPhD/F/22/34178Department of Science, Innovation and TechnologyDiabetes UK 22/0006503Diabetes UK 23/0006626Early Postdoc Mobility Fellowship P2FRP2_181432Engineering and Physical Sciences Research Council EP/R513052/1HORIZON EUROPE Marie Sklodowska-Curie Actions 893158PhD Plus Programme PhD2022∖100020Queen Mary University of London Principal PrizeRoyal Academy of Engineering CiET2021∖94University of BaselUniversity of Oxford Strategic Research Fund
6 · The paper itself

Abstract

Modulating biomaterial properties using light holds great promise for biomedical applications, such as drug delivery, as it is non-invasive and offers both spatial and temporal control. Visible light is particularly salient for stimulation of cell-interfacing materials, as it is cyto-compatible; however, this limits the number of photoswitches appropriate for these applications. In this work, we use donor-acceptor Stenhouse adduct (DASA) functionalized polymers comprising poly(ethylene glycol)-b-poly(hexyl methacrylate) to make visible light-responsive polymersomes, and use these to encapsulate a model drug cargo. We demonstrate that release of the model cargo can be triggered using visible light when the polymersomes are loaded into poly(ethylene glycol) hydrogels. Moreover, ON/OFF switchable cargo release was demonstrated by modulating the light stimulation of the hydrogel. We envisage this could be used to dynamically modulate hydrogel properties in clinically relevant applications for controlled delivery of small molecule therapeutic agents, such as advanced in vitro tissue models and implantable drug-eluting scaffolds.

Indexed as

HydrogelsDrug Delivery SystemsDrug LiberationLightMethacrylatesPolyethylene GlycolsHydrogelsMethacrylatesPolyethylene GlycolsDonor–acceptor Stenhouse adductsDrug releaseHydrogelsPhotoswitchesPolymersomes

Identifiers

PMID41619178
PMCPMC13087835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.