Evidence map›Paper›PMID 41619122›Full record

ReviewHuman cell2026

The interplay between circadian rhythm components and apoptosis in health and disease.

Mohammad Rafi Khezri, Somayeh Mohammadi Panah, Morteza Ghasemnejad-Berenji, Hojat Ghasemnejad-Berenji, Saeed Mehrzadi, Amin Abdollahzade Fard, Aysa Rezabakhsh, Maryam Rahnama

Abstract readReview
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In one paragraph

Review in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Rafi Khezri *Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, 5715799313, Iran. Drmnkh76@gmail.com.ORCID http://orcid.org/0000-0002-4280-0378
Somayeh Mohammadi Panah *Urmia University of Medical Sciences, Urmia, Iran.
Morteza Ghasemnejad-BerenjiDepartment of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.ORCID http://orcid.org/0000-0001-5672-9202
Hojat Ghasemnejad-BerenjiReproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, 5715799313, Iran.
Saeed MehrzadiRazi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amin Abdollahzade FardNephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Aysa RezabakhshPatient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Maryam RahnamaUrmia University of Medical Sciences, Urmia, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, circadian rhythm regulates the expression of numerous protein-coding genes across nearly all cell types, playing a central role in maintaining health. However, circadian rhythm components interact with a wide variety of intracellular signaling pathways. Through these interactions, the circadian system interfaces with various pathologies by governing different molecular mechanisms. Evidence suggests that the interaction between circadian rhythms and apoptosis plays a pivotal role in both health and disease, warranting careful investigation. Apoptosis, one of the main mechanisms of programmed cell death, is essential for establishing maintaining cellular homeostasis in the human body. Alterations in apoptotic activity occur during the progression of cancer, as well as in various autoimmune and neurodegenerative diseases. Conversely, bidirectional interactions between circadian components and apoptotic factors offer new insights into disease development. Therefore, this review highlights the links between circadian rhythms and apoptosis across health and disease states, aiming to identify potential therapeutic interventions based on this connection.

Indexed as

ApoptosisCircadian RhythmHealthAnimalsAutoimmune DiseasesHomeostasisHumansNeoplasmsNeurodegenerative DiseasesSignal TransductionApoptosisCircadian rhythmsDiseaseHealth

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.