Evidence map›Paper›PMID 41619088›Full record

ReviewMikrochimica acta2026

Current status and future challenges of transition-metal oxides as enzyme-mimetics for detection of clinically relevant biomarkers: a comprehensive review.

Mani Arivazhagan, Shanmugam Paramasivam, Lalitha Gnanasekaran, Shanmugapriya D, Samikannu Prabu, Supakorn Boonyuen, Ayyanu Ravikumar, Arunjegan Amalraj, Jaroon Jakmunee

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mani ArivazhaganResearch Laboratory for Analytical Instrument and Electrochemistry Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Shanmugam ParamasivamDepartment of Biomaterials, Saveetha Dental College and Hospital, SIMATS, Saveetha University, Chennai, 600 077, India. shanmugachem@gmail.com.
Lalitha GnanasekaranInstituto de Alta Investigación, Universidad de Tarapacá, Arica, 1000000, Chile.
Shanmugapriya DVicerrectoría de Investigación y Postgrado, Universidad de La Serena, La Serena, 1700000, Chile.
Samikannu PrabuGraduate Institute of Environmental Engineering, National Central University, No.300, Chung-Da Road, Chung-Li District, Tao-Yuan City, 32001, Taiwan.
Supakorn BoonyuenDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Klong Luang, Pathum Thani, 12121, Thailand. chemistrytu@gmail.com.
Ayyanu RavikumarSchool of environment and safety engineering, Jiangsu university, Zhenjiang, 212013, Jiangsu, China.
Arunjegan AmalrajSchool of environment and safety engineering, Jiangsu university, Zhenjiang, 212013, Jiangsu, China.
Jaroon JakmuneeResearch Laboratory for Analytical Instrument and Electrochemistry Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand. jaroon.jakmunee@cmu.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging technologies in healthcare are driving the rapid evolution of advanced sensing and diagnostic systems, paving the way for faster and more accurate predictive and preventive medical applications. The recent identification of numerous biomarkers is linked with early disease detection and screening via real samples. These biomarkers are early warning systems, providing reliable and precise insights into the presence and progression of diseases. In recent years, the strategic utilization of functional transition metal oxides-based nanomaterials are diverse and in combination with electroanalytical techniques have enabled the rapid, sensitive, and selective detection and monitoring of a broad spectrum of biomarkers in body fluids. Given the trace-level concentrations of many biomarkers in bodily fluids, the implementation of signal amplification techniques is critical to enhance detection sensitivity and ensure accurate biomarker quantification. Transition metal oxides-based nanostructures are widely employed to enhance signal output in electrochemical biomarker detection, owing to their excellent catalytic properties and high surface-to-volume ratios. To improve signal sensitivity in electrochemical biomarker detection, transition metal oxide nanostructures are frequently utilized due to their superior electrocatalytic activity, high conductivity, and large active surface areas. This review will examine the recent developments and trends in the use of transition metal oxides for electrochemical biomarker detection via enzyme-mimetics strategy.

Indexed as

BiomarkersElectrochemical TechniquesOxidesTransition ElementsBiosensing TechniquesHumansNanostructuresBiomarkersOxidesTransition ElementsBiomarkersBody fluidsClinical diagnosticsElectroanalytical techniquesExcellent catalytic activityPhysiological conditionsTransition metallic oxides

Identifiers

PMID41619088

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.