Evidence map›Paper›PMID 41619074›Full record

ArticleMikrochimica acta2026

The preparation of two molecularly imprinted electrochemical sensors based on gold nanoparticles and glutaraldehyde and their application in protein detection.

Menggai Jia, Yingqi Li, Ziyao Qin, Longwei Li, Ling Peng, Molin Yang, Beibei Hu, Zhiwei Li, Shiguo Sun

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Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Menggai Jia *College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China.
Yingqi Li *College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China.
Ziyao QinCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China.
Longwei LiCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China.
Ling PengCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China.
Molin YangDermatology Department, the Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050018, P. R. China.
Beibei HuCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China. hub2018@hebust.edu.cn.
Zhiwei LiCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang, 050018, P. R. China. lizhizwei@hebust.edu.cn.
Shiguo SunShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P.R. China. sunsg@nwsuaf.edu.cn.

Funding

Hebei Research Center of Pharmaceutical and Chemical Engineering No.225676121HMilitary Logistics Open Scientific Research Project No. CLB21C009the Hebei Natural Science Foundation No. H2025208002the Youth Science and Technology Project of Hebei Provincial Department of Health No. 20241758
6 · The paper itself

Abstract

Two modified electrochemical molecularly imprinted polymer electrochemical sensors (MIP/AuNPs/GCE and MIP/GA@CS/AuNPs/GCE) were prepared for the detection of the clinically relevant protein biomarkers, including BSA, Histone, IGF-1, CRP, HSA, GSH, and β-LG. MIP/AuNPs/GCE were prepared by simple modification of AuNPs onto the GCE, which can detect proteins containing free sulfhydryl groups only. To broaden the detection scope, MIP/GA@CS/AuNPs/GCE were prepared, modified by chitosan (CS) and glutaraldehyde (GA) to form hydrogen bonds and Schiff bases with proteins, thereby enabling efficient protein immobilization. The result shows that the MIP/AuNPs/GCE sensor can only detect BSA, HSA, GSH and β-LG, which have the free sulfhydryl groups. While the MIP/GA@CS/AuNPs/GCE sensor can detect all seven proteins. Combined with molecular imprinted polymer technology, the optimized MIP/GA@CS/AuNPs/GCE sensor exhibited a broader capability for protein detection. The MIP/GA@CS/AuNPs/GCE sensor demonstrated excellent selectivity, a wide detection range, and high sensitivity, with a detection limit down to the fM level. This method is applicable for the detection of protein biomarkers, providing innovative technical support for clinical diagnosis, bioanalytical chemistry, and protein separation and extraction.

Indexed as

Biosensing TechniquesElectrochemical TechniquesGlutaralGoldMetal NanoparticlesMolecular ImprintingMolecularly Imprinted PolymersProteinsChitosanHumansLimit of DetectionChitosanGlutaralGoldMolecularly Imprinted PolymersProteinsDifferential pulse voltammetryGlutaraldehydeGold nanoparticlesModified glassy-carbon electrodeSulfhydryl groupsSurface molecularly imprinted electrochemical sensor

Identifiers

PMID41619074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.