Evidence map›Paper›PMID 41619073›Full record

SynthesisNeurosurgical review2026

Long-term outcomes of ventricular entry in high grade glioma resection: A meta-Analysis and meta regression.

Bryan Gervais de Liyis, Selfy Oswari, Muhammad Kusdiansah, Ryan Keswani, Muhammad Reza Arifianto, Sayyid Abdil Hakam Perkasa, Yunus Kuntawi Aji, Amal Rizky, Muhammad Hafif, Fadhil Panyalai and 3 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bryan Gervais de LiyisDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia. bgliyis@gmail.com.ORCID http://orcid.org/0000-0002-8272-754X
Selfy OswariDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-7994-8333
Muhammad KusdiansahDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-8182-6415
Ryan KeswaniDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-9770-7322
Muhammad Reza ArifiantoDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-2698-2511
Sayyid Abdil Hakam PerkasaDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-8111-7723
Yunus Kuntawi AjiDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-1877-6312
Amal RizkyDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0009-0003-6133-4143
Muhammad HafifDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0003-4744-9975
Fadhil PanyalaiDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.
Adi SulistyantoDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0000-0002-3989-2945
Mustaqim PrasetyaDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0009-0005-1812-9421
Abrar ArhamDepartment of Neurosurgery, National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, MT Haryono Street, Cawang, Kramat Jati, Jakarta, 13630, Indonesia.ORCID http://orcid.org/0009-0004-6200-0281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ventricular entry (VE) in high-grade gliomas (HGGs) has been hypothesized to predispose patients to adverse events and poor outcomes; however, the extent remains unclear. This study aimed to systematically evaluate the impact of VE in patients with HGG. A PROSPERO-registered (CRD420251053281) systematic search was conducted in the ScienceDirect, Scopus, PubMed, Google Scholar, and Cochrane databases to identify longitudinal studies up to June 2025. Primary outcomes included leptomeningeal dissemination (LMD), distant parenchymal recurrence (DPR), and hydrocephalus. Additionally, survival analysis with Kaplan-Meier curve and meta-regression were conducted to assess survival patterns and identify study-level moderators contributing to heterogeneity. Seventeen studies involving 4,086 participants (mean age 57.24 ± 11.21 years; 52.26% male) met the inclusion criteria. VE was significantly associated with increased risks of LMD (RR 2.23; 95% CI 1.61-3.11; p < 0.001) and hydrocephalus (RR 3.57; 95% CI 1.88-6.80; p < 0.001), but not DPR in the overall analysis. Survival analysis revealed that VE is associated with increased mortality (HR 1.12; 95% CI 1.03-1.21) up to 84 months. Meta-regression revealed that prior treatment was inversely associated with LMD, whereas increasing age, male sex, glioblastoma histology, and receipt of chemotherapy or radiotherapy were positively associated with DPR. In contrast, non-methylated status and radiotherapy were inversely associated with hydrocephalus. VE in HGGs may be associated with increased risks of LMD, hydrocephalus, and reduced survival. However, these associations should be regarded as provisional.

Indexed as

Brain NeoplasmsCerebral VentriclesGliomaNeurosurgical ProceduresFemaleHumansHydrocephalusMaleTreatment OutcomeGliomaHydrocephalusLeptomeningeal metastasisProgression-Free survivalVentricular entry

Identifiers

PMID41619073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.