ArticleMolecular genetics and genomics : MGG2026
Northeast india: genetic inconsistency across ethnicity and geography.
Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
North East India served as a crucial route for the movement of modern humans, connecting the Indian subcontinent with East and Southeast Asia due to its strategic location near the Himalayas and the Bay of Bengal. Archaeological and anthropological research indicates migration and cultural exchange in this region, along with the Tibetan plateau to the north. To understand the complex genetic patterns here, we conducted a detailed analysis of the Mizo population and its various clans in North-East India, a unique and independent group for which genomic historical records are currently unavailable. We examined 110 individuals from seven different Mizo clans using one hundred thousand autosomal markers (Sequence data accession number EGAS00001008205). Our haplotype-based analysis revealed that the Mizo people belong to the same clade as the Trans-Himalayan group, suggesting a common origin from a shared ancestral population. Additionally, our study identified seven genetic clusters among the Mizo clans, with many clans spanning more than one cluster; notably, a distinct population structure was evident even across small geographical distances. The results also show that the Mizo genetic profile differs from that of East and Southeast Asian populations. Allelic frequency-based analyses indicated that a novel Trans-Himalayan ancestry unites all the populations of this region. The findings suggest a complex genetic structure in North-East India, which contrasts sharply with the genetic landscape observed in East and South-East Asia. Therefore, we conclude that the interplay of language, ethnicity, and geography shapes the genetic makeup of the Mizo population and its clans.
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