Evidence map›Paper›PMID 41619031›Full record

ArticleMikrochimica acta2026

CuO

Qi Fang, Lilin Wu, Chongwen Luo, Yanyan Chen, Yuzhu Zhou, Xiaohuan Guo, Kun Hu, Changchun Wen

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi Fang *State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Lilin Wu *State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Chongwen LuoSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Yanyan ChenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Yuzhu ZhouState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Xiaohuan GuoState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China. goxan_xh@163.com.
Kun HuState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China. hukun216@gxnu.edu.cn.
Changchun WenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China. wcchun@163.com.

Funding

National Natural Science Foundation of China 22167005Natural Science Foundation of Guangxi Zhuang Autonomous Region 2025GXNSFAA069183
6 · The paper itself

Abstract

The high content of glutathione (GSH) and the deficiency of hydrogen peroxide (H2O2) in tumor cells seriously affect the efficiency of chemodynamic therapy (CDT). Developing a tumor-specific CDT therapeutic agent that can continuously supply H2O2 and deplete GSH is of great significance for increasing the production rate of reactive oxygen species (ROS) and improving the efficiency of CDT. Herein, we propose a self-supplying H2O2 and highly efficient catalytic integrated CDT therapeutic platform. By constructing a CuO2-coated cobalt-doped ZIF-8 nanoplatform (CuO2@Co/ZIF-8), achieve self-supplying H2O2 and GSH depletion for efficient breast cancer treatment. The tumor micro-acidic environment triggers the decomposition of CuO2, continuously supplying H2O2 and generating Cu2+, while Cu2+ consumes GSH to form Cu+. Co2+ and Cu+ catalyze the generation of ∙OH from H2O2. This synergistic mechanism not only overcomes the limitations of single materials in H2O2 supply and catalytic efficiency, but also significantly enhances the therapeutic effect of CDT. Our work significantly improves the efficacy of CDT by optimizing the supply of H2O2 and catalytic efficiency. The synergistic application of Co/ZIF-8 and CuO2 provides a new efficient and safe strategy for chemodynamic tumor therapy.

Indexed as

Antineoplastic AgentsBreast NeoplasmsCobaltCopperHydrogen PeroxideImidazolesZeolitesCatalysisFemaleGlutathioneHumansMCF-7 CellsMetal-Organic FrameworksAntineoplastic AgentsCobaltCoppercupric oxideGlutathioneHydrogen PeroxideImidazolesMetal-Organic FrameworksZeolitesZIF-8 metal-organic frameworkBreast cancerChemodynamic therapyGlutathioneSelf-generated H2O2

Identifiers

PMID41619031

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.