Evidence map›Paper›PMID 41618953›Full record

GuidelineGenetics in medicine : official journal of the American College of Medical Genetics2026

Consideration of inherited cancer risk on a continuum: An international and multidisciplinary perspective: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).

Tuya Pal, Joseph Christopher, Esteban Astiazaran-Symonds, William D Foulkes, Paul James, Susan Klugman, Allison Kurian, Julie Mak, Alvaro Monteiro, Mark Robson and 4 more

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Genetics in medicine : official journal of the American College of Medical Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Reply to Chi et al.: DefiningProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tuya PalDepartment of Medicine, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, TN.
Joseph ChristopherEast Anglian Medical Genetics Service, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Genomic Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.
Esteban Astiazaran-SymondsDepartment of Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ.
William D FoulkesDepartments of Human Genetics, Oncology and Medicine, McGill University, Montréal, QC, Canada.
Paul JamesSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia.
Susan KlugmanDivision of Reproductive and Medical Genetics, Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.
Allison KurianDepartment of Medicine and of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA.
Julie MakUniversity of California San Francisco Health Center for Clinical Genetics and Genomics, San Francisco, CA.
Alvaro MonteiroDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL.
Mark RobsonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Marc TischkowitzEast Anglian Medical Genetics Service, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Genomic Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.
Douglas R StewartClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Helen HansonPeninsula Clinical Genetics, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom.
ACMG Professional Practice and Guidelines Committee. Electronic address: documents@acmg.netAmerican College of Medical Genetics and Genomics, Bethesda, MD.

Funding

Genetic Modifiers of Cancer RiskZIACP010142 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MIRABELLO, LISA · 2009 to 2025
$17.1M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010142
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Breast cancerGenomicsInherited cancersRisk communicationRisk continuum

Identifiers

PMID41618953
PMCPMC12866959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.