Evidence map›Paper›PMID 41618920›Full record

ArticleCartilage2026

Semaphorin 7A Regulates the Balance Between Cartilaginous and Fibrous Tissues in the Repair Process of Articular Cartilage Damage.

Ryosuke Hatada, Kengo Abe, Akihiro Yamashita, Nanao Horike, Sho Obata, Atsushi Kumanogoh, Shuichi Matsuda, Noriyuki Tsumaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryosuke HatadaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kengo AbeDepartment of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akihiro YamashitaDepartment of Tissue Biochemistry, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Nanao HorikeDepartment of Tissue Biochemistry, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Sho ObataDepartment of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Shuichi MatsudaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Noriyuki TsumakiDepartment of Tissue Biochemistry, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID 0000-0002-0520-3654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveDamage to the joint-surface repair itself as fibrocartilage, a mixture of cartilaginous and fibrous tissues, which leads to debilitating conditions with persistent joint pain. The regulatory mechanisms that control the formation of these tissues are poorly understood.MethodsWe analyzed single-cell RNA-sequencing data from the repaired tissue formed in a chondral defect model of the monkey knee joint to identify genes specifically expressed in the repaired tissue. We used primary chondrocytes from semaphorin 7A (Sema7A) knockout mice to analyze the function of Sema7A in the dedifferentiation of chondrocytes

Indexed as

articular cartilage repairfibrocartilagehyaline cartilagesemaphorin7a

Identifiers

PMID41618920
PMCPMC12861400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.