Evidence map›Paper›PMID 41618913›Full record

ArticleJournal of natural products2026

Rules for Dibenzocyclooctadiene Conformational Dynamics.

Luke P Robertson, Wen Xu, Louisa Brieskorn, Iro Chaitoglou, Jing Guo, Runyue Huang, Per-Johan Jakobsson, Gennaro Pescitelli, Ulf Göransson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luke P RobertsonPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 75123, Sweden.ORCID 0000-0001-5987-2426
Wen XuState Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Louisa BrieskornDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Solna, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm 17176, Sweden.
Iro ChaitoglouDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Solna, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm 17176, Sweden.
Jing GuoPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 75123, Sweden.
Runyue HuangSection of Rheumatology and Immunology Research, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, China.
Per-Johan JakobssonDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Solna, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm 17176, Sweden.
Gennaro PescitelliDipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Giuseppe Moruzzi, 13, Pisa 56124, Italy.ORCID 0000-0002-0869-5076
Ulf GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 75123, Sweden.ORCID 0000-0002-5005-9612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conformational dynamics of flexible compounds can meaningfully influence their NMR spectra and biological activities, yet these effects are easily overlooked. The dibenzocyclooctadiene lignans provide a clear example of this. Although >350 naturally occurring dibenzocyclooctadienes have been published, discrete spectral features have gone unnoticed, and misconceptions about their conformational dynamics pervade the literature. Our attention was drawn to this after observing

Indexed as

CyclooctanesKadsuraLignansMolecular ConformationMolecular StructureNuclear Magnetic Resonance, BiomolecularCyclooctanesdibenzocyclooctadienedibenzocyclooctadiene lignanLignans

Identifiers

PMID41618913
PMCPMC12954843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.