Evidence map›Paper›PMID 41618877›Full record

ArticleThe Journal of physiology2026

A model of β-adrenergic stimulation in human ventricular cells for tissue-scale simulations of sympathetically modulated tachycardias.

Kelly Zhang, Karl Magtibay, Natalia Trayanova, Edward Vigmond

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kelly ZhangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8666-4569
Karl MagtibayInstitut de Mathématiques de Bordeaux, Université de Bordeaux, Talence, Gironde, France.ORCID 0000-0001-5846-5327
Natalia TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-8661-063X
Edward VigmondInstitut de Mathématiques de Bordeaux, Université de Bordeaux, Talence, Gironde, France.ORCID 0000-0003-1388-3589

Funding

CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Agence Nationale de la Recherche ANR-10-IAHU-04Fondation Leducq 16 CVD 02NHLBI NIH HHS T32 HL007024
6 · The paper itself

Abstract

Ventricular tachycardia (VT) dynamics in myocardial infarction and heart failure patients could be influenced by heterogeneous sprouting of sympathetic nerves or alteration of β-adrenergic receptors to disrupt normal β-adrenergic receptor signalling (BARS). Because sympathetic remodelling is challenging to control experimentally, we created and validated a novel ionic model incorporating the macroscopic effects of BARS on intracellular Ca

Indexed as

Heart VentriclesModels, CardiovascularMyocytes, CardiacReceptors, Adrenergic, betaSympathetic Nervous SystemTachycardia, VentricularAction PotentialsCalciumComputer SimulationHumansCalciumReceptors, Adrenergic, betaadrenergicelectrophysiologymodelsimulationsympathetictachycardiaventricle

Identifiers

PMID41618877
PMCPMC12953024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.