ArticleThe Journal of international medical research2026
"When the virus ages with the patient": Disease-specific quality of life in individuals with hepatitis B virus infection in Ghana.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundThis study examined disease-specific quality of life among people living with chronic hepatitis B virus infection in northern Ghana, where the condition remains highly endemic.MethodUsing a cross-sectional design, 264 individuals with chronic hepatitis B virus infection were recruited from 1 regional hospital and 3 district hospitals. Data were collected through structured interviews using the validated hepatitis B virus quality of life (HBQoL) instrument and analyzed using descriptive statistics and logistic regression.ResultParticipants had a mean age of 38 years (±16.5), with a nearly equal sex distribution. The overall global HBQoL mean score was 63.6 (±20.0), reflecting a moderate quality of life. Regression analysis identified age, hepatitis B virus profile, and the presence of complications as significant predictors. Each additional year of age increased the odds of better quality of life by 2.8% (odds ratio = 1.028, p = 0.002). Hepatitis B envelope antigen negativity was inversely associated with high quality of life (odds ratio = 0.344, p = 0.013). Additionally, the absence of hepatitis B virus complications was associated with lower odds of good quality of life in this population (odds ratio = 0.300, p = 0.001).ConclusionsThe findings suggest that psychosocial and clinical interventions should complement biomedical care. Addressing the unique quality of life challenges of people living with the hepatitis B virus is essential for holistic management in Ghana and similar settings.
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