Evidence map›Paper›PMID 41618723›Full record

ArticleClinical transplantation2026

Normothermia Machine Perfusion Is Associated With Reduced Transfusion Requirements, Improved Hemodynamic Stability, and Decreased Vasopressor Use During the Postreperfusion Phase of Liver Transplantation.

Xian Zhao, Samer Ebaid, Nickolas Feduska, Christian Park, Fady Kaldas, Christopher Wray, Victor W Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xian ZhaoDepartment of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Samer EbaidDepartment of Surgery, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Nickolas FeduskaDepartment of Surgery, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Christian ParkDepartment of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Fady KaldasDepartment of Surgery, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-4888-3979
Christopher WrayDepartment of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-7755-0161
Victor W XiaDepartment of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-1182-3179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNormothermic machine perfusion (NMP) has emerged as a valuable preservation technique, expanding the donor pool and improving clinical outcomes in liver transplantation (LT). Despite its growing adoption and reported advantages, the perioperative impact of NMP remains incompletely defined. In this study, we aimed to investigate the effects of NMP versus static cold storage (SCS) on postreperfusion blood product utilization, hemodynamics, and vasopressor requirements.

methodsWe conducted a retrospective cohort study of adult LT patients at our institution between January 2017 and November 2024. The NMP and SCS groups were matched using propensity scores generated from preoperative and prereperfusion variables.

resultsA total of 1059 patients underwent LT, including 86 NMP and 973 SCS patients. Before matching, significant differences were noted in several preoperative and prereperfusion variables. After 1:3 propensity match, these differences were eliminated. Post-match analysis showed that the NMP group required significantly fewer transfusions (approximately 40% reduction observed across all blood products). NMP was also associated with significantly higher mean arterial pressure and reduced vasopressor requirements following reperfusion.

conclusionsNMP was associated with reduced blood transfusion, improved hemodynamic stability, and decreased vasopressor support during the postreperfusion phase of LT.

Indexed as

Blood TransfusionHemodynamicsLiver TransplantationOrgan PreservationPerfusionVasoconstrictor AgentsFemaleFollow-Up StudiesGraft SurvivalHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsVasoconstrictor Agentscomplicationorgan perfusion and preservationsurgical/technicaltransfusion

Identifiers

PMID41618723
PMCPMC12859740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.