Trial reportClinical oral implants research2026
Effect of Connective Tissue Graft as an Adjunct to Guided Bone Regeneration in the Surgical Treatment of Peri-Implantitis: A Dual-Center Randomized Controlled Trial.
Trial report in Clinical oral implants research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04323540 (Surgical Reconstructive Treatment of Peri-Implantitis With or Without Simultaneous Soft Tissue Augmentation), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surgical Reconstructive Treatment of Peri-Implantitis With or Without Simultaneous Soft Tissue Augmentation: a Multi-center Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesTo evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri-implantitis treatment. MATERIALS AND
methodsThirty-two patients with peri-implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group, CG). Clinical and radiographic parameters were recorded at baseline, 6, and 12 months. The primary outcome was the change in clinical attachment level (CAL), while secondary outcomes included pocket probing depth (PPD), bleeding on probing (BoP), plaque index (PI), keratinized mucosa width (KMW), mucosal thickness (MT), recession (REC), suppuration (SUP), marginal bone levels (MBL), bone defect morphology, and disease resolution (DR).
resultsAt 12 months, CAL gain was significantly higher in TG compared with CG (3.21 ± 1.57 mm vs. 1.65 ± 1.28 mm; p = 0.022), and TG achieved significantly greater increase in KMW (2.25 ± 2.89 mm vs. 0.26 ± 1.49 mm; p = 0.010). Both groups showed significant PPD reduction, with a greater, though not statistically significant, improvement comparing TG with CG (3.25 ± 1.59 mm vs. 1.97 ± 1.23 mm; p = 0.052). Additionally, MBL improved significantly in both groups (p < 0.001), with higher gains in TG (p < 0.001). However, DR was comparable between the two groups.
conclusionsGBR effectively improves peri-implant parameters after 1 year. Adding a CTG enhances CAL and KMW gains and may promote more favorable bone levels, although the impact on DR remains inconclusive. Long-term studies are warranted to confirm these findings.
trial registrationClinicalTrials.gov NCT04323540.
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