ArticleJournal of veterinary pharmacology and therapeutics2026
Pharmacokinetics, Optimal Dosages, and Withdrawal Time of Florfenicol in Cobia (Rachycentron canadum) After Oral Administration via Medicated Feed.
Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Antimicrobial drugs are commonly used for the treatment of bacterial diseases in cobia (Rachycentron canadum), but information regarding the rationale of their therapeutic use, such as pharmacokinetics (PK), optimal dosages, and withdrawal time (WDT) in this species is very rare. The present study evaluated the PK characteristics of florfenicol (FF) in cobia at 25°C after a single oral administration of 10 mg/kg via medicated feed. FF in the serum was determined by an HPLC method and the PK parameters were analyzed by a one-compartmental model. In tissue depletion and drug WDT study, cobia were fed with FF medicated feed at 10 mg/kg once daily for 5 days. The WDT was determined by linear regression analysis using the sum of FF and its metabolite florfenicol amine as the marker residue. The results revealed that FF has desirable PK characteristics in cobia, including a high peak serum concentration (C
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