ArticleThe Journal of clinical endocrinology and metabolism2026
Overnight wakefulness impairs next-day postprandial glucose in young women independent of sex hormones.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextEstradiol and progesterone may influence glucose regulation, but it remains unclear whether ovarian hormone levels modulate night shift-induced impairments in glucose metabolism.
objectiveTo investigate the effects of a night shift-like schedule on next-morning fasting and postprandial glucose metabolism in reproductive-aged women.
methodsFifty-two women with an HbA1c <5.7% completed a protocol consisting of one night of sleep and one night of wakefulness in a laboratory environment. After each night, fasting blood samples were collected to measure estradiol, progesterone, insulin, leptin, and adiponectin. Insulin resistance was estimated using HOMA-IR, and the leptin-to-adiponectin ratio (LAR)-a marker of fasting and postprandial insulin sensitivity-was calculated. Morning postprandial glucose responses were assessed using an oral glucose tolerance test (OGTT), and substrate utilization was measured via respiratory quotient (RQ) using indirect calorimetry. Linear mixed-effects models were used to test the effects of condition and the progesterone-to-estradiol (P/E) ratio on all outcomes.
resultsFasting glucose, HOMA-IR, and LAR did not differ between conditions. Post-OGTT blood glucose at 60 minutes (mean estimated difference: 0.58 mmol/L, P = .016) and peak glucose (0.42 mmol/L, P = .037) were higher following the night shift compared with sleep. The P/E ratio was not significantly associated with fasting or postprandial glucose. Pre-OGTT RQ was lower after the night shift (-0.029, P < .001), and adjusting for pre-OGTT RQ attenuated the post-OGTT glucose differences between conditions (P ≥ .097).
conclusionOne night of wakefulness-as occurs in night shift work-impaired next-morning glucose tolerance in women, independent of ovarian hormone variation. Accordingly, choosing low-glycemic index foods for the first meal after a night shift may help reduce postprandial glucose excursions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.