Evidence map›Paper›PMID 41618652›Full record

ArticleThe New phytologist2026

Circular RNA Vv-circCOR27 modulates thermotolerance through attenuating VvHSP90.2b-VvHsfA7a interaction in grapevine.

Yi Ren, Yuanyuan Xu, Moyang Liu, Lipeng Zhang, Yue Song, Junpeng Li, Jingjing Liu, Dongying Fan, Zhen Zhang, Juan He and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yi RenCollege of Landscape and Horticulture, Yunnan Agricultural University, Kunming, Yunnan, 650201, China.ORCID https://orcid.org/0009-0006-8918-146X
Yuanyuan XuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0001-5895-9001
Moyang LiuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0002-9853-681X
Lipeng ZhangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yue SongShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0009-0005-9787-3864
Junpeng LiShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0009-0005-8406-8233
Jingjing LiuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0009-0001-8755-6903
Dongying FanShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0009-0000-8220-2789
Zhen ZhangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0001-6740-6441
Juan HeShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jiuyun WuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0009-0002-1560-5734
Qian ZhaShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0002-0660-3684
Zhen GaoState Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, 271018, China.ORCID https://orcid.org/0000-0001-6163-8663
Zheng'an YangCollege of Landscape and Horticulture, Yunnan Agricultural University, Kunming, Yunnan, 650201, China.
Chao MaShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0001-6111-494X

Funding

AI+ project of Shanghai Municipal Education Commission 2024AIZD010Earmarked Fund for China Agriculture Research System CARS-29National Natural Science Foundation of China 32202446National Natural Science Foundation of China 32341041
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules that arise from exon back-splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown. This study employed genetic transformation, circRNA pull-down assay, ribonucleoprotein immunoprecipitation (RIP), and the circRNA trimolecular fluorescence complementation (cTriFC) system to investigate the function and regulatory mechanisms of a circRNA Vv-circCOR27 in grapevine. Vv-circCOR27 expression was suppressed under heat stress and was markedly lower in thermotolerant cultivars. In addition, overexpression of Vv-circCOR27, using an expression cassette with endogenous introns inserted into circRNA-producing exons to minimize the background level of cognate linear RNA, was shown to exacerbate thermotolerance in grapevine embryogenic calli and seedlings. Biochemical assays demonstrate that Vv-circCOR27 binds directly to heat shock protein 90.2b (VvHSP90.2b). Further evidence indicated that Vv-circCOR27 inhibits the interaction between VvHsfA7a and VvHSP90.2b in vivo, which resulted in the downregulation of small heat shock protein (sHSP) genes under heat stress in Vv-circCOR27 overexpression calli. Collectively, this finding suggests a model in which thermotolerance is fine-tuned by Vv-circCOR27 via competitively binding to VvHSP90.2b, thereby attenuating its interaction with VvHsfA7a and subsequent transactivation. This work advances understanding of circRNA regulatory mechanisms in plants.

Indexed as

HSP90 Heat-Shock ProteinsPlant ProteinsRNARNA, PlantThermotoleranceVitisGene Expression Regulation, PlantHeat-Shock ResponsePlants, Genetically ModifiedProtein BindingRNA, CircularHSP90 Heat-Shock ProteinsPlant ProteinsRNARNA, CircularRNA, Plantcircular RNAgrapevineheat shock factorheat stressHSP90

Identifiers

PMID41618652
PMCPMC13000974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.