Evidence map›Paper›PMID 41618603›Full record

ArticleEuropean journal of endocrinology2026

Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood.

Amy R Blinder, Dina Sapiro, Jessica E Baker, Zhaoping Qin, Irina Bancos, Melanie L Lyden, William F Young, Heather Wachtel, Debbie L Cohen, Lydia Kürzinger and 10 more

Abstract read
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In one paragraph

Article in European journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Amy R BlinderDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.
Dina SapiroDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.
Jessica E BakerDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.
Zhaoping QinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0003-2439-5417
Irina BancosDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0001-9332-2524
Melanie L LydenDivision of Endocrine Surgery, Mayo Clinic, Rochester, MN 55905, United States.
William F YoungDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN 55905, United States.
Heather WachtelDepartment of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, United States.ORCID 0000-0003-3786-3638
Debbie L CohenDepartment of Medicine, Division of Renal, Electrolyte and Hypertension, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, United States.
Lydia KürzingerDepartment of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg 97080, Germany.
Martin FassnachtDepartment of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg 97080, Germany.ORCID 0000-0001-6170-6398
James M LutherDepartment of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Tracy Ann WilliamsMedical Department IV, LMU Hospital, Ludwig-Maximilians-University Munich, Munich 80336, Germany.ORCID 0000-0002-2388-6444
Martin ReinckeMedical Department IV, LMU Hospital, Ludwig-Maximilians-University Munich, Munich 80336, Germany.ORCID 0000-0002-9817-9875
Adina F TurcuDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48019, United States.
Tobias ElseDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48019, United States.ORCID 0000-0002-2262-0011
Thomas J GiordanoRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, United States.
Aaron M UdagerRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0002-8254-5404
William E RaineyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.
Kazutaka NanbaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0002-6475-5141

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Primary Aldosteronism Subtypes: Pathophysiology and Steroid SignaturesR01HL155834 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2021 to 2025
$3.5M
11-Oxyandrogens and Aging: Health ImplicationsR01AG080516 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Adina F Turcu · 2023 to 2026
$2.3M
The Genetics of Primary AldosteronismR01HL130106 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSE, TOBIAS · 2016 to 2020
$1.9M
A genotype-phenotype study of germline succinate dehydrogenase pathogenic variantsK08CA270385 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Heather Wachtel · 2022 to 2026
$967k
Skeletal Consequences of Mild Autonomous Cortisol SecretionK23DK121888 · NIDDK · MAYO CLINIC ROCHESTER · PI BANCOS, IRINA · 2019 to 2022
$630k
American Heart Association 17SDG33660447Deutsche Forschungsgemeinschaft RE 752/31-1Deutsche Forschungsgemeinschaft WI 5359/2-1German Conn's Registry-Else-Kröner Hyperaldosteronism Registry 2013_A182German Conn's Registry-Else-Kröner Hyperaldosteronism Registry 2015_A171German Conn's Registry-Else-Kröner Hyperaldosteronism Registry 2019_A104Humboldt FoundationJapan Heart FoundationNCINCI NIH HHS K08 CA270385NCI NIH HHS K08CA270385NHLBI NIH HHS R01HL130106NHLBI NIH HHS R01HL155834NIA NIH HHS 1R01AG080516NIA NIH HHS R01 AG080516NIDDK NIH HHS DK096994NIDDK NIH HHS DK106618NIH Cancer Center P30CA068485NIH HHS K23DK121888Takeda Science FoundationVanderbilt Translational Pathology Shared Resource
6 · The paper itself

Abstract

objectiveRecent studies suggest a unique disease profile in elderly patients with primary aldosteronism (PA), who have a high prevalence of comorbidities and low clinical cure rate post-adrenalectomy. This study aims to investigate histopathology and genetic characteristics of PA in late adulthood.

methodsFormalin-fixed, paraffin-embedded adrenal tissue sections from 114 patients with PA who underwent unilateral adrenalectomy at age 60 or older were used. Aldosterone synthase (CYP11B2) immunohistochemistry (IHC) was performed for histopathologic analysis. Somatic DNA variants were identified in aldosterone-producing tissue following CYP11B2 IHC-guided sequencing.

resultsHistopathologic analysis revealed that 56 adrenals contained an aldosterone-producing nodule (APN) (49%), 44 contained an aldosterone-producing adenoma (APA) (39%), 7 contained multiple APN (6%), and 7 contained only non-functioning adenomas [NFA, of which 6 had at least one aldosterone-producing micronodule (APM) in the adjacent tissue] (6%). NFAs were also identified alongside APN/APA in 24 cases. An APN was the most common histologic subtype in men (51/88, 58%), while APA was predominant in women (18/26, 69%). Of 67 APNs with successful sequencing, the majority had variants in CACNA1D (40/67, 60%). KCNJ5 variants were the most common alteration in APA (14/44, 32%).

conclusionsOlder individuals with lateralized PA exhibit distinct genetic and histologic causes of disease with sex differences in mutation prevalence and adrenal histopathology. In APN, the most frequently altered gene is CACNA1D, while KCNJ5 variants are most common in APA. Unlike young patients with PA, the presence of NFA is a frequent observation in late adulthood individuals with PA.

Indexed as

Adrenal GlandsHyperaldosteronismAdenomaAdrenal Cortex NeoplasmsAdrenalectomyAdrenocortical AdenomaAgedAldosteroneCalcium Channels, L-TypeCytochrome P-450 CYP11B2FemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHumansMaleMiddle AgedMutationAldosteroneCACNA1D protein, humanCalcium Channels, L-TypeCytochrome P-450 CYP11B2G Protein-Coupled Inwardly-Rectifying Potassium ChannelsKCNJ5 protein, humanaldosterone-producing adenomaaldosterone-producing noduleCYP11B2sexual dimorphismsomatic variant

Identifiers

PMID41618603
PMCPMC13276716

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