Evidence map›Paper›PMID 41618568›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2026

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.

Kalle J Niemi, Valtteri Kaasinen, Rimona S Weil, Juho Joutsa

Abstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kalle J NiemiTurku Brain and Mind Center, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0003-3960-0815
Valtteri KaasinenClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-3446-7093
Rimona S WeilUCL Dementia Research Centre, Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-5092-6325
Juho JoutsaTurku Brain and Mind Center, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-3457-9415

Funding

The Finnish Cultural FoundationThe Finnish Parkinson FoundationThe Finnish Society of Nuclear MedicineTurun YliopistoTurun Yliopistollinen KeskussairaalaTurun Yliopistollisen Keskussairaalan Koulutus- ja TutkimussäätiöTurun YliopistosäätiöWellcome Trust
6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood.

objectivesThe aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers Initiative data.

methods[

resultsCross-sectionally, depression was associated with reduced ventral striatum (VS) binding at 2- and 4-year and dorsal raphe (DRN) at 4-year follow-up (P

conclusionsThe findings provide novel information about the monoaminergic networks underlying depression, anxiety, and RBD in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Behavioral SymptomsBiogenic MonoaminesCognitive DysfunctionParkinson DiseaseREM Sleep Behavior DisorderAgedAnxietyBrainConnectomeCross-Sectional StudiesDepressionDopaminergic ImagingFemaleHumansMaleMiddle Aged2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneBiogenic MonoaminesTropanes[123I]FP‐CITanxietydepressionParkinson's diseaserapid‐eye‐movement (REM) sleep behavior disordersingle‐photon emission computed tomography (SPECT)

Identifiers

PMID41618568
PMCPMC13067308

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.