ArticleBMC chemistry2026
Novel and sustainable microfabricated Cu ion selective sensor doped with ionophore and supported with docking study for determination of vonoprazan fumarate in tablet dosage form.
Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Colorimetric glucose biosensing based on peroxidase-mimicking activity of Fe,N co-doped carbon dots.RSC advances · 2026Article
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5 authors.
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Abstract
In the field of drug analysis, there is a growing emphasis on developing techniques that are environmentally friendly, cost-effective, and efficient. To align with the principles of green analytical chemistry and to support the advancement of portable and handheld devices, an innovative microfabricated ion selective electrode (ISE) has been developed for the detection of Vonoprazan fumarate (VON). The development of this electrode involved a two-step optimization process. Initially, a range of ionophores were screened to determine the one with the highest selectivity for VON. Through molecular docking studies, gamma-cyclodextrin (γ-cyclodextrin) was identified as demonstrating maximal activity towards VON. The second optimization step involved incorporating a graphene nanocomposite as an ion to electron transducer layer between the γ-cyclodextrin polymeric membrane and the microfabricated copper (Cu) solid contact ISE. This nanocomposite layer contributed to enhanced stability, reduced potential drift, and rapid response times (approximately 30 s), likely due to its hydrophobic properties that prevent water layer formation at the interface between the Cu electrode and the polymeric membrane. The VON sensor was characterized according to IUPAC guidelines, revealing a linear dynamic range of 2.00 × 10⁻
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