ArticleTrials2026
Multimodal Prehabilitation In Pancreatic cancer Patients undergoing surgery (PIPS): study protocol for a randomized controlled trial.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06069297 (Multimodal Prehabilitation in Localized Pancreatic Cancer Patients Undergoing Surgery), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Prehabilitation in Localized Pancreatic Cancer Patients Undergoing Surgery: a Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundPancreatic cancer surgery is challenging and associated with up to a 70% complication rate, which translates to poor postoperative recovery and patient health-related quality of life (HRQoL). Previous studies showed that preoperative low functional capacity and malnutrition have been associated with inferior postoperative outcomes. Considering the high frequency of older and frail patients, often deconditioned by long-course neoadjuvant chemotherapy, the preoperative period, including the time window after chemotherapy, is a unique opportunity to condition modifiable risk factors (e.g., functional capacity, nutritional status). This manuscript outlines the protocol for a randomized controlled trial investigating the impact of a multimodal prehabilitation program on postoperative complications and recovery following pancreatectomy.
methodsThis is a single-center, randomized controlled trial evaluating a 4-6-week multimodal prehabilitation program (physical, nutritional, and psychological interventions) compared with usual perioperative care in adults scheduled for pancreatic surgery, whether upfront or following chemotherapy for pancreatic or periampullary cancer. The primary outcome will be the severity of postoperative complications, measured using the Comprehensive Complication Index (CCI DISCUSSION: A multimodal prehabilitation program may enhance functional capacity, improve nutritional status, and increase skeletal muscle mass, thereby promoting a shift from a catabolic to an anabolic state. By modulating systemic inflammation and supporting cardiovascular and immune function, this strategy could lead to fewer postoperative complications, a shorter length of stay, and a faster recovery of health-related quality of life. Positive findings from this trial would carry strong clinical significance and could be practice-changing, potentially informing future guidelines for the implementation of multimodal prehabilitation in patients undergoing pancreatic cancer surgery.
trial registrationTrial Registry NCT06069297. Registered on August 25, 2023.
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