Evidence map›Paper›PMID 41618401›Full record

ArticleJournal of ovarian research2026

RLIP depletion suppresses ovarian cancer growth and metastasis.

B Madhu Krishna, Pankaj Garg, David Horne, Prakash Kulkarni, Ravi Salgia, Sharad S Singhal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B Madhu KrishnaDepartment of Medical Oncology and Therapeutic Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA.
Pankaj GargDepartment of Chemistry, GLA University, NH-19, Mathura-Delhi Road, Mathura, Uttar Pradesh, 281406, India.
David HorneDepartment of Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, and National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA.
Prakash KulkarniDepartment of Medical Oncology and Therapeutic Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA.
Ravi SalgiaDepartment of Medical Oncology and Therapeutic Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA.
Sharad S SinghalDepartment of Medical Oncology and Therapeutic Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA. ssinghal@coh.org.ORCID http://orcid.org/0000-0002-6415-8160

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

highlightsKey findings of this study with potential clinical relevance include:• RLIP is an attractive therapeutic target with the ability to suppress human OC at multiple stages of development.• Reducing RLIP levels significantly inhibits OC cell growth and enhances apoptosis compared with controls.• RLIP blockade/depletion may serve as a broad-spectrum therapeutic strategy that remains effective regardless of common pathway differences among OC subtypes.• This is the first evidence from integrated in vitro and in vivo studies demonstrating the strong therapeutic promise of RLIP-targeting agents for treating metastatic OC.

Indexed as

Ovarian NeoplasmsAnimalsApoptosisATP-Binding Cassette TransportersCell Line, TumorCell ProliferationFemaleGTPase-Activating ProteinsHumansMiceNeoplasm MetastasisXenograft Model Antitumor AssaysATP-Binding Cassette TransportersGTPase-Activating ProteinsRALBP1 protein, humanAntisenseChemotherapeuticsGlutathione-conjugatesMercapturic acid pathwayMetastasisOrthotopic mouse modelOvarian cancerRLIP

Identifiers

PMID41618401
PMCPMC12930995

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.