ArticleAntimicrobial resistance and infection control2026
Natural clearance of colonization with vancomycin-resistant Enterococcus and carbapenemase-producing Enterobacterales: a 13-year study among territory-wide residents of residential care home for the elderly in Hong Kong.
Article in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Natural clearance time and effect of manuka honey body wash and oral probiotics on colonization ofFrontiers in public health · 2026Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundVancomycin-resistant Enterococcus (VRE) and carbapenemase-producing Enterobacterales (CPE) cause outbreaks in hospitals and the community. There is limited literature on the clearance time of VRE and CPE colonization. We reported the natural clearance time of VRE and CPE among residents of the Residential Care Home for the Elderly (RCHE) and the factors associated with prolonged colonization.
methodsThis retrospective study reviewed cases of VRE and CPE colonization reported to the Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region from 1 January, 2012 to 31 December, 2024. We reviewed the demographic characteristics and outcomes of the VRE and CPE cases when they were cleared of the bacteria or died during the follow-up period, up to 31 December 2024. Clearance of VRE and CPE was defined as negative culture results for at least two and three consecutive specimens collected at least 48 h apart at the RCHE respectively. We compared the clearance time of VRE and CPE using the Kaplan-Meier method and determined the factors influencing the duration of clearance by univariate and multiple Cox regression.
resultsA total of 3626 VRE cases and 4434 CPE cases were followed up. CPE cases tended to be older and had a higher proportion of females compared to VRE cases. There was no statistical difference in the types of homes between the two groups. The mortality rate of VRE (25.7%) was similar to that of CPE (25.1%). It was found that the carriage duration of CPE was significantly longer than that of VRE, as tested by the log-rank test (p < 0.01). Half of the VRE and CPE cases will clear the bacteria by 85 days and 131 days, respectively. The carriage duration for the majority (90%) of VRE and CPE cases was 400 and 818 days, respectively. After adjusting for all associated factors, a longer length of stay for readmission to hospitals and lower occupancy rates in RCHEs were significantly associated with prolonged carriage status.
conclusionsThe natural clearance duration of VRE and CPE provides useful information to improve guidelines of screening of previously colonized patients, and duration of contact precautions to prevent transmission of these resistant organisms among the vulnerable groups.
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