ArticleVirology journal2026
The impact of maternal flavivirus infections on fetal neurological outcomes: a scoping review.
Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
This scoping review examines the neurological effects of maternal flavivirus infection, specifically Zika virus (ZIKV), Dengue virus (DENV), and Yellow Fever virus (YFV), on fetal brain development. Inclusion criteria focused on studies involving maternal infection and neurodevelopmental outcomes in offspring up to five years of age. The review found that ZIKV, especially the African Strain, exhibited neuroviolence and pronounced fetal brain abnormalities. Despite the presence of transplacental maternal transfer, these antibodies did not fully prevent congenital malformations, including microcephaly and developmental delays. Diagnostic limitations, such as serological cross-reactivity, particularly in regions where multiple flaviviruses co-circulate, were shown to impede effective clinical management. Additionally, the review highlights stark disparities in health infrastructure and prenatal care in Latin America, where the burden of Congenital Zika Syndrome (CZS) is disproportionately high. Findings emphasize the need for strain-specific diagnostics and therapeutics, along with long-term cohort studies that integrate virological, immunological, and socio-environmental perspectives. Ultimately, this review underscores the urgent need for equitable public health strategies and continued interdisciplinary research to address the teratogenic risks associated with maternal flavivirus infections.
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