Evidence map›Paper›PMID 41618285›Full record

ArticleBMC musculoskeletal disorders2026

Kinematic alignment yields a reduced knee adduction moment and better range of motion compared to mechanical alignment: biomechanical considerations of a staged, bilateral total knee arthroplasty case.

Letizia Mancini, Giovanni Spallone, Arianna Carnevale, Stefano Campi, Carlo Casciaro, Emiliano Schena, Pieter D'Hooghe, Reha N Tandogan, Rocco Papalia, Umile Giuseppe Longo

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In one paragraph

Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Letizia Mancini *Fondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Giovanni Spallone *Fondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Arianna CarnevaleFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Stefano CampiFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Carlo CasciaroFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Emiliano SchenaFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Pieter D'HoogheDepartment of Orthopaedic Surgery and Sports Medicine, Aspetar Hospital, Doha, 29222, Qatar.
Reha N TandoganDepartment of Orthopedics and Traumatology, Ortoklinik & Çankaya Hospital, Ankara, 06540, Turkey.
Rocco PapaliaFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Umile Giuseppe LongoFondazione Policlinico Universitario Campus Bio-Medico, Via Álvaro del Portillo, 200, 00128, Rome, Italy. g.longo@unicampus.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This technical note describes an intra-subject comparison between mechanical and kinematic alignment in total knee arthroplasty (TKA), based on gait analysis performed before and after staged bilateral procedures. Our quantitative assessment revealed differences in joint range of motion, moment profiles, and ground reaction forces between the two limbs. The kinematically aligned knee showed greater multi-planar mobility, higher sagittal moments, and a more physiological gait pattern. These findings highlight the added value of dynamic biomechanical analysis in evaluating the functional impact of alignment strategies, offering insights that go beyond static imaging and supporting more personalized approaches in TKA.

Indexed as

Arthroplasty, Replacement, KneeKnee JointOsteoarthritis, KneeRange of Motion, ArticularBiomechanical PhenomenaGaitGait AnalysisHumansKinematic alignmentKnee biomechanicsKnee osteoarthritisMechanical alignmentTotal knee arthroplasty

Identifiers

PMID41618285
PMCPMC12879381

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.