Evidence map›Paper›PMID 41618233›Full record

ArticleBMC musculoskeletal disorders2026

The METTL3-IGF2BP3 axis drives osteosarcoma progression by enhancing ID1 mRNA stability.

Rongbing Shu, Qiuxin Cheng, Zhuanyi Yu, Huaqiang Zhou, Mingchao Lin, Minghong Shi, Jianhe Chen, Jingxiang Chen, Min Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongbing ShuDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Qiuxin ChengDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Zhuanyi YuDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Huaqiang ZhouDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Mingchao LinDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Minghong ShiDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Jianhe ChenDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Jingxiang ChenDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China.
Min ZhaoDepartment of Orthopedics, Yingtan People's Hospital, No. 1, Longhushan North Avenue, Yingtan, Jiangxi Province, 335000, China. zhaominytrmyy@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteosarcoma (OS) is a highly aggressive malignant bone tumor. While ID1 plays a critical role in OS progression, the underlying mechanisms remain unclear. This study investigates the METTL3-IGF2BP3 axis-mediated N6-methyladenosine (m

methodsRNA-binding proteins (RBPs) associated with ID1 were predicted using the ENCORI database. Differentially expressed RBP genes (RBP-DEGs) were screened via the GSE253548 dataset, and core RBP-DEGs were identified using machine learning algorithms. m

resultsBioinformatics analysis identified METTL3 and IGF2BP3 as core regulators of ID1, with elevated ID1, IGF2BP3, and METTL3 expression observed in OS cells. Mechanistically, IGF2BP3 enhanced ID1 mRNA stability by binding to m

conclusionThe METTL3-IGF2BP3 axis facilitates OS progression by enhancing ID1 mRNA stability and expression, highlighting its potential as a therapeutic target.

Indexed as

Bone NeoplasmsInhibitor of Differentiation Protein 1MethyltransferasesOsteosarcomaRNA-Binding ProteinsRNA StabilityAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMice, NudeRNA, MessengerID1 protein, humanIGF2BP3 protein, humanInhibitor of Differentiation Protein 1MethyltransferasesMETTL3 protein, humanRNA-Binding ProteinsRNA, MessengerID1IGF2BP3m6AMETTL3mRNA stabilityOsteosarcoma

Identifiers

PMID41618233
PMCPMC12930876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.