Evidence map›Paper›PMID 41618217›Full record

ArticleBMC neurology2026

Risk factors affecting the age at onset in adult patients with multiple sclerosis.

Mahsa Mohammadi Lapevandani, Sanaz Khodadadi, Khadije Haji Naghitehrani, Saeideh Ayoubi, Sharareh Eskandarieh, Mohammad Ali Sahraian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahsa Mohammadi LapevandaniMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran.
Sanaz KhodadadiMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran.
Khadije Haji NaghitehraniDepartment of Neurology, Islamic Azad University, Tehran, Iran.
Saeideh AyoubiMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran.
Sharareh EskandariehMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran.
Mohammad Ali SahraianMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran. Sahraian1350@yahoo.com.

Funding

Tehran University of Medical Sciences and Health Services 1403-2-101-73381
6 · The paper itself

Abstract

Several factors can predispose patients to experience a sooner onset of multiple sclerosis (MS). In this study, we aimed to investigate the possible effect of environmental factors on the age at onset of adult-onset MS.Methods In this cross-sectional study, 6802 MS patients with age at onset after 18 years old and below 50 years old were included. Descriptive and regression analysis was applied to assess the correlation between age at onset and environmental factors.Results Chronic diseases and reproductive history were associated with a later onset, while smoking showed a complex relationship with onset timing.Conclusion Environmental factors can possibly alter the age at MS onset in adults.

Indexed as

Multiple SclerosisAdolescentAdultAge of OnsetCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsSmokingYoung AdultEnvironmentalMultiple sclerosisOnsetRisk factors

Identifiers

PMID41618217
PMCPMC13063615

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.