SynthesisBMC musculoskeletal disorders2026
Investigating the therapeutic impact of platelet-rich plasma on knee, hip, and traumatic osteoarthritis: a meta-analysis and systematic review.
Synthesis in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Platelet-Rich Plasma Versus Bone Marrow Aspirate Concentrate for Hip Disorders: A Narrative Review of Biological Rationale, Clinical Evidence, and Research Priorities.Bioengineering (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to assess the therapeutic effectiveness and safety of platelet-rich plasma (PRP) in the management of primary and posttraumatic osteoarthritis (OA) patients.
methodsA comprehensive literature search was conducted in the following databases: PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP database, Wanfang Database, and China Biology Medicine Disc for all double-blind randomized controlled trials (RCTs) on the use of PRP in TOA until November 2025. The data extraction and quality assessment were carried out independently by two researchers. The RevMan5.4 statistical software was used to perform a meta-analysis of the data that met the inclusion criteria.
resultsEleven RCTs involving 851 participants were included. PRP injection resulted in a significant improvement in the WOMAC Total score compared to control treatments in primary OA (SMD: -8.53; 95% CI: -14.52 to -2.55; p = 0.005). Subgroup analyses revealed that this benefit was significant in patients younger than 60 years and with both single and double-dose regimens. However, no significant overall effects were observed for the WOMAC Pain, WOMAC Stiffness, VAS, or KOOS subscales. PRP was associated with more transient adverse events, primarily injection-site reactions.
conclusionsIntra-articular PRP injection is an effective treatment for improving overall function in patients with primary OA, particularly in younger individuals. While it demonstrates a acceptable safety profile, its effects on specific pain and quality-of-life measures require further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.