Evidence map›Paper›PMID 41618168›Full record

ArticleBMC gastroenterology2026

Transjugular liver biopsy in patients with unexplained liver dysfunction and bleeding tendency: a safety and efficacy analysis.

Zhiyuan Zheng, Minjie Yang, Lili Ma, Jingqin Ma, Zihan Zhang, Jian Wang, Yuan Ji, Shiyao Chen, Jianjun Luo, Zhiping Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhiyuan Zheng *Department of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Minjie Yang *Department of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Lili MaEndoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Jingqin MaDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Zihan ZhangDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Jian WangEndoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuan JiDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shiyao ChenEndoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Jianjun LuoDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Zhiping YanDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. yan.zhiping@zs-hospital.sh.cn.
Xiaolin WangDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. 18211320012@fudan.edu.cn.
Wen ZhangDepartment of Interventional Radiology, Zhongshan Hospital Fudan University, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. zhang.wen2@zs-hospital.sh.cn.

Funding

the National Key Research and Development Program of China No. 24YFC2417505
6 · The paper itself

Abstract

backgroundTransjugular liver biopsy (TJLB) enables histopathological diagnosis of liver disease and simultaneous assessment of the hepatic venous pressure gradient (HVPG).

aimsTo assess the diagnostic adequacy and safety of TJLB in combination with HVPG measurement in patients with unexplained Liver Dysfunction and hemorrhage tendency.

methodsSeventy-seven TJLB procedures were performed in 58 patients with unexplained liver dysfunction using the COOK Medical TJLB kit. Biopsy quality was assessed by specimen length, number of complete portal tracts, diagnostic yield, and procedure-related complications. Subgroup analyses were conducted according to HVPG levels.

resultsAll procedures yielded adequate histopathological samples. The mean specimen length was 8 mm (range, 5–13 mm), with a mean of 9 complete portal tracts (range, 4–20). TJLB identified the underlying etiology in 72.4% of patients, including 70.7% of those with ascites and 72.7% of those with coagulopathy. Among patients who underwent HVPG measurement, higher HVPG values were associated with shorter specimen length and fewer portal tracts. No procedure-related complications were observed.

conclusionsTJLB combined with HVPG measurement is a safe and effective approach for diagnosing liver disease in patients with unexplained liver dysfunction and bleeding tendency.

Indexed as

LiverLiver DiseasesAdultAgedBiopsyFemaleHepatic VeinsHumansJugular VeinsMaleMiddle AgedPortal PressureHepatic venous pressure gradientTransjugular liver biopsyUnexplained liver dysfunction

Identifiers

PMID41618168
PMCPMC12930547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.