Evidence map›Paper›PMID 41618139›Full record

ArticleBMC molecular and cell biology2026

Isolation and characterization of mesenchymal stem cells from nasal polyps and olfactory mucosa: a comparative analysis of proliferation and multi-lineage differentiation capacity.

Negin Khosravi, Zahra Pourmohammadi-Bejarpasi, Mehryar Habibi Roudkenar, Samin Abed, Ehsan Kazemnezhad Leyli, Shadman Nemati

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Negin KhosraviOtorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Zahra Pourmohammadi-BejarpasiBurn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Mehryar Habibi RoudkenarBurn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Samin AbedOtorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Ehsan Kazemnezhad LeyliOtorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Shadman NematiOtorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. drshadmannemati_ent@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNasal polyps (NPs) and olfactory mucosa (OM) are emerging as potential sources of mesenchymal stem cells (MSCs), which hold promise for regenerative medicine due to their multipotent differentiation capabilities. This study aimed to isolate MSCs from nasal polyps (NP-MSCs) and evaluate their differentiation potentials in comparison with healthy olfactory mucosa (OM-MSCs).

methods16 human samples from NP and OM tissues were studied and MSCs were isolated enzymatically. Flow-cytometry analysis was done to characterize the isolated cells; then, tri-lineage differentiation capacity of SCs into osteoblasts, adipocytes, and neurons was evaluated using the differentiation mediums. Finally, the proliferation rate was assessed by Cell Counting Kit-8.

resultsThe outgrowth of cells from NP tissue was observed approximately three days earlier than that from OM tissue. OM-MSCs and NP‐MSCs showed expression of CD markers of mesenchymal cells, including CD105, CD73, CD90, and CD44, but not the markers of hematopoietic cells including CD14, CD45, CD34, and HLA-DR. Cell viability and proliferation rates of NP‐MSCs and OM‐MSCs were both high, and significantly higher in OM-MSC (p-value < 0.001). The multi-lineage differentiation (osteogenic, adipogenic, and neurogenic) of OM-MSCs and NP-MSCs was confirmed.

conclusionThese results showed that MSCs are present in NPs with noticeable differentiation potentials. These cells may play some roles in the pathogenesis of NP. Additionally, nasal polyps, as biowastes, represent a potential novel source of MSCs.

Indexed as

Cell DifferentiationMesenchymal Stem CellsNasal PolypsOlfactory MucosaAdultAntigens, CDCell LineageCell ProliferationCells, CulturedCell SeparationCell SurvivalFemaleHumansMaleMiddle AgedAntigens, CDCell differentiationMesenchymal stem cellMultipotent stem cellNasal polypOlfactory mucosa

Identifiers

PMID41618139
PMCPMC12930925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.