Evidence map›Paper›PMID 41618092›Full record

ArticleScientific reports2026

Interaction of pulsed low frequency electromagnetic field (PEMF) with mitochondria.

Sergejs Zavadskis, Andreas Sebastian Gasser, Miriam Karas, Sara Kostrebic, Jonas Flatscher, Annette Vaglio-Garro, Peter Dungel, Heinz Redl, Johannes Grillari, Adelheid Weidinger and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sergejs ZavadskisLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Andreas Sebastian GasserLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Miriam KarasLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Sara KostrebicLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Jonas FlatscherLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Annette Vaglio-GarroLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Peter DungelLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Heinz RedlLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Johannes GrillariLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Adelheid WeidingerLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Paul SlezakLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Andrey V KozlovLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria. andrey.kozlov@trauma.lbg.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulsed electromagnetic field (PEMF) therapy is a non-invasive treatment that delivers electric and magnetic fields to tissues via inductive coils inducing salutary effects. Previously PEMF was reported to accelerate gas transport in the liquid phase. Drawing analogies from electrical elements, we hypothesized that PEMF can modulate transmembrane potential of biological membranes. Given that mitochondria interact with gaseous molecules such as oxygen and nitric oxide (NO) and contain voltage-sensitive channels, this study focused on the effects of a single PEMF device with a low input-energy and a 1ms, 30 kHz sine wave duty cycle per pulse on mitochondrial function. Experiments were conducted using cell cultures, tissue homogenates, and isolated mitochondria. We assessed mitochondrial membrane potential, NO levels, and mitochondrial respiration. We found no evidence that PEMF restores mitochondrial respiration inhibited by NO, but it can be restored by exposure of mitochondria to blue light. Our findings show that PEMF selectively stimulates respiration linked to ATP-synthesis affecting less uncoupled respiration. This suggests that changes in ATP-synthesis underlies the primary beneficial effects observed here. The underlying mechanisms may include interaction of PEMF with mitochondrial transport systems or activity of mitochondrial complexes. The exact mechanisms still should be investigated.

Indexed as

Electromagnetic FieldsMitochondriaAdenosine TriphosphateAnimalsBlue LightCell RespirationMembrane Potential, MitochondrialNitric OxideOxygen ConsumptionAdenosine TriphosphateNitric Oxide

Identifiers

PMID41618092
PMCPMC12914018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.