ArticleNature communications2026
The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex.Nature communications · 2026Article
- Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026Article
- Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations With Cognition and Functioning.Human brain mapping · 2026Article
- Age-related changes in brain signal variability in autism spectrum disorder.Molecular autism · 2025Article
- Mapping multi-modal dynamic network activity during naturalistic music listening.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Imbalanced temporal states of cortical blood-oxygen-level-dependent signal variability during rest in episodic migraine.The journal of headache and pain · 2024Article
- Reliability of variability and complexity measures for task and task-free BOLD fMRI.Human brain mapping · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.bioRxiv : the preprint server for biology · 2024Article
- Electroencephalography Spectral-power Volatility Predicts Problem-solving Outcomes.Journal of cognitive neuroscience · 2024Article
- covSTATIS: a multi-table technique for network neuroscience.Aperture neuro · 2024Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- Mapping high-amplitude fMRI edge time series events across space and time.Imaging neuroscience (Cambridge, Mass.)Article
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13 authors.
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Abstract
Variability drives the organization and behavior of complex systems, including the human brain. Understanding the variability of brain signals is thus necessary to broaden our window into brain function and behavior. Few empirical investigations of macroscale brain signal variability have been undertaken, given the difficulty in separating biological sources of variance from artefactual noise. Here, we characterize the temporal variability of the most predominant macroscale brain signal, the fMRI BOLD signal, and systematically investigate its statistical, topographical, and neurobiological properties. We contrast fMRI acquisition protocols, and integrate across histology, microstructure, transcriptomics, neurotransmitter receptor and metabolic data, fMRI static connectivity, and empirical and simulated magnetoencephalography data. We show that BOLD signal variability represents a spatially heterogeneous, central property of multi-scale multi-modal brain organization, distinct from noise. Our work establishes the biological relevance of BOLD signal variability and provides a lens on brain stochasticity across spatial and temporal scales.
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