ArticleScientific reports2026
Clinical relevance of tissue copper, selenium, and cadmium alterations in colorectal cancer.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Applications of Machine Learning in the Research of Heavy Metal(loid)s-Related Risk: A Scoping Review of Methodology.Toxics · 2026Review
- Exploratory comparative profiling of 22 macro- and trace elements reveals disrupted elemental homeostasis in colorectal cancer tissues.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Imbalances in essential elements and altered levels of toxic elements are thought to play a role in colorectal cancer (CRC) development. This study assessed the concentrations of selected elements in CRC tissues and explored their associations with clinical parameters. Paired samples of tumor tissue and adjacent noncancerous tissue were collected from 62 patients with confirmed CRC. After microwave-assisted acid digestion, ten elements (Al, Cr, Mn, Fe, Ni, Cu, Zn, Se, Sr, Cd) were quantified using ICP-MS. Statistical analyses and machine-learning methods were applied to identify features discriminating clinical and demographic subgroups. Significant differences between tumor and healthy tissues were observed for Mn, Cu, Zn, Se, Sr, and Cd, with further variation linked to Tumor Node Metastasis (TNM) classification, clinical stage, and place of residence. Cadmium levels were higher in the healthy tissues of women (p_adj = 0.021), while selenium concentrations showed a decreasing trend with advancing disease (Stage I vs. III; p = 0.017, p_adj = 0.051). Boruta analysis identified lymph node status, TNM stage, and elevated tumor copper levels as key features associated with CRC. Elemental profiles in CRC tissues differ markedly from those in adjacent healthy tissues and exhibit meaningful associations with disease stage and sex. The distinctive copper pattern observed in tumor samples, together with clinical parameters, suggests that elemental profiling may complement standard diagnostic approaches and contribute to a deeper understanding of CRC biology.
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