Evidence map›Paper›PMID 41617923›Full record

ArticleCommunications biology2026

Structural analysis reveals that water molecules mediate self-activation of GPR99.

Miaofang Xiao, Xiaoling Bao, Yusheng Guo, Jiawei Li, Tiancai Chang, Fumei Zhong, Xiaomin Mao, Mu Li, Siqi Liu, Wanbiao Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miaofang Xiao *The Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Xiaoling Bao *Scientific Research Center of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yusheng Guo *The Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-5826-299X
Jiawei Li *Department of Geriatric Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
Tiancai Chang *The Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Fumei Zhong *The Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Xiaomin MaoThe Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Mu LiThe Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Siqi LiuThe Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.
Wanbiao ChenCenter for Human Tissues and Organs Degeneration, Faculty of Pharmaceutical Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Limin ZhaoDepartment of Geriatric Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
Chongyuan WangCenter for Human Tissues and Organs Degeneration, Faculty of Pharmaceutical Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China. cy.wang@siat.ac.cn.ORCID http://orcid.org/0000-0001-7477-5376
Heng LiuThe Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China. 2022991053@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-2654-4287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPR99 holds promise as a potential therapeutic target for inflammatory diseases. GPR99 exhibits marked basal activity when coupled with the G

Indexed as

Receptors, G-Protein-CoupledWaterBinding SitesCryoelectron MicroscopyHEK293 CellsHumansModels, MolecularProtein BindingProtein ConformationSignal TransductionReceptors, G-Protein-CoupledWater

Identifiers

PMID41617923
PMCPMC12960956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.