ArticleLasers in medical science2026
Comparison of PDT using a 660 nm laser and methylene blue vs. an 810 nm laser and indocyanine green on different Candida species - in vitro.
Article in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhotodynamic therapy (PDT) offers broad-spectrum antifungal effects with lower resistance in some studies. This study evaluates the effectiveness of two PDT protocols, using a 660 nm diode laser with methylene blue (MB) compared to an 810 nm diode laser with indocyanine green (ICG), in reducing colony counts of Candida albicans, C. glabrata, C. tropicalis, and C. krusei.
methodsThis experimental laboratory study tested 4 standard Candida species in seven groups (2 PDT, 2 photosensitizers alone, 2 lasers wavelength with saline, 1 control with saline) each containing five replicates per species. PDT was performed using MB with a 660 nm diode laser and ICG with an 810 nm diode laser. Laser exposure setting was 100 mW, 10 J/cm², 100 s. CFUs were quantified, and statistical analysis was performed using SPSS version 26, with significance set at P < 0.05.
resultsPDT had better efficacy for colony count reduction of C. tropicalis, and C. krusei. PDT with an 810 nm diode laser and ICG had better efficacy than PDT with 660 nm diode laser and MB but difference was not significant (P > 0.05). For some candida species there was no significant difference between PDT with laser alone for colony reduction but there was significant difference between them with each photosensitizer and saline alone (P < 0.05).
conclusionBoth PDT had better efficacy for colony count reduction of C. tropicalis, and C. krusei compare to other two species. PDT with diode 810 nm and ICG seems better than PDT with diode 660 nm and MB, but the difference was not statistical between two methods.
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