Evidence map›Paper›PMID 41617827›Full record

ArticleMolecular psychiatry2026

Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors.

Hongling Guo, Tahir Ali, Qixing Yang, Jianxun Xia, Yanhua Luo, Jiayan Ren, Zuxin Chen, Ying Han, Shupeng Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongling GuoState Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China. hongling.guo@pku.edu.cn.ORCID http://orcid.org/0000-0001-7157-355X
Tahir AliState Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China.
Qixing YangShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.
Jianxun XiaYunkang School of Medicine and Health, Nanfang College, Guangzhou, 510970, Guangdong, China.ORCID http://orcid.org/0000-0002-5771-9695
Yanhua LuoState Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China.
Jiayan RenShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.
Zuxin ChenShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.ORCID http://orcid.org/0000-0002-5412-3140
Ying HanNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing, 100191, China.ORCID http://orcid.org/0000-0002-8381-4071
Shupeng LiState Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China. lisp@pku.edu.cn.ORCID http://orcid.org/0000-0002-7807-374X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress increases the risk of developing depression. However, the neurological mechanism by which chronic stress elicits depression remains largely unknown. Here, we identify that somatostatin-positive neurons in the zona incerta (ZI

Indexed as

DepressionSomatostatinZona IncertaAnimalsDisease Models, AnimalGyrus CinguliHabenulaMaleNeuronsStress, PsychologicalVesicular Glutamate Transport Protein 2SomatostatinVesicular Glutamate Transport Protein 2

Identifiers

PMID41617827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.