Evidence map›Paper›PMID 41617682›Full record

ArticleCell death & disease2026

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma.

Chong Chen, Du Cai, Xuanhui Liu, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu and 10 more

Abstract read
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chong Chen *Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.ORCID http://orcid.org/0009-0006-5148-9821
Du Cai *Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Xuanhui Liu *Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Yifan ZhengDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Xinxin HuangDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Dongwen ChenDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Jiawei CaiDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Yiran BieDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Zhengran ZhouDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Chuling HuDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Zhengyu WeiDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Kuntai CaiPrecision Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, PR China.
Ting LiDepartment of Gastroenterology and Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, 410013, PR China.
Shuzhen LuoInstitute of Intelligent Medical Research (IIMR), BGI Genomics, Shenzhen, PR China.
Dongbing LiuInstitute of Intelligent Medical Research (IIMR), BGI Genomics, Shenzhen, PR China.ORCID http://orcid.org/0000-0003-2870-5187
Kui WuInstitute of Intelligent Medical Research (IIMR), BGI Genomics, Shenzhen, PR China.ORCID http://orcid.org/0000-0002-6857-7231
Zerong CaiDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Feng GaoDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.ORCID http://orcid.org/0000-0002-0500-5527
Xiaojian WuDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China. wuxjian@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-5610-2530
Peishan HuDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China. hupsh3@mail.sysu.edu.cn.

Funding

Guangzhou Science and Technology Program key projects 2023A04J1819Hunan Provincial Science and Technology Department (Department of Science and Technology of Hunan Province) 2024RC3229National Natural Science Foundation of China (National Science Foundation of China) 81972212Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2021A1515011767Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2024JJ4026
6 · The paper itself

Abstract

The acidic tumor microenvironment provides the energy that drives the development of malignant tumors. High concentrations of lactic acid and H

Indexed as

Colorectal NeoplasmsSulfate TransportersTumor MicroenvironmentAnimalsCell Line, TumorChloride-Bicarbonate AntiportersDisease ProgressionELAV-Like Protein 1Gene Expression Regulation, NeoplasticHumansMiceMice, Inbred BALB CMice, NudeChloride-Bicarbonate AntiportersELAV-Like Protein 1SLC26A3 protein, humanSulfate Transporters

Identifiers

PMID41617682
PMCPMC12877128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.