Evidence map›Paper›PMID 41617671›Full record

ArticleCell death discovery2026

Trim15 stabilizes VDAC3 via ubiquitination to suppress autophagy and enhance chemosensitivity in hypopharyngeal squamous cell carcinoma.

Guangyi Wang, Yibang Shen, Lin Wang, Tao Fu, Yichuan Huang, Fangyu Chai, Mingjin Xu, Yan Jiang, Jisheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guangyi Wang *Key Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Yibang Shen *Key Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Lin Wang *Key Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Tao FuKey Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Yichuan HuangKey Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Fangyu ChaiWeihai Central Hospital, Weihai, Shandong, China.
Mingjin XuDepartment of Radiation Oncology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Yan JiangKey Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. jiangyanoto@qdu.edu.cn.
Jisheng ZhangKey Laboratory, Department of Otolaryngology-Head and Neck Surgery, Shandong Engineering Research Center for Precision Diagnosis and Treatment in Otolaryngology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. zhangjs@qdu.edu.cn.ORCID http://orcid.org/0000-0001-9674-8483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypopharyngeal squamous cell carcinoma (HPSCC) is a highly aggressive malignancy with a poor prognosis. This study elucidates the role of the E3 ubiquitin ligase Tripartite Motif Containing 15 (Trim15) and its substrate, mitochondrial voltage-dependent anion channel 3 (VDAC3), in regulating autophagy, mitophagy, and chemoresistance in HPSCC. We found that Trim15 is significantly downregulated in HPSCC tissues and inhibits cell proliferation and migration in FaDu and Detroit 562 cells. Trim15 stabilizes VDAC3 via K6-linked ubiquitination, thereby suppressing autophagy and mitophagy while elevating reactive oxygen species (ROS) levels. VDAC3 knockdown enhances autophagy and mitophagy, concomitantly reducing ROS and promoting cancer cell survival. High-concentration ethanol suppresses Trim15 and VDAC3 expression, suggesting an adaptive response to oxidative stress. Notably, chloroquine (CQ), an autophagy inhibitor, enhances HPSCC sensitivity to 5-fluorouracil (5-FU), with synergistic effects observed in xenograft models. These findings establish the Trim15-VDAC3-mitophagy axis as a critical regulator of HPSCC progression and chemoresistance, offering a novel therapeutic target for augmenting the efficacy of autophagy inhibitors in combination with standard chemotherapy.

Identifiers

PMID41617671
PMCPMC12876940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.